Gallic Acid: Review of the Methods of Determination and Quantification

Fernandes, Felipe Hugo Alencar; Salgado, Hérida Regina Nunes

doi:10.1080/10408347.2015.1095064

Cited by 221 publications

(112 citation statements)

References 73 publications

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“…Quercetin is a flavonoid with high antioxidant and antibacterial activities against S. aureus and E. coli (Rauha et al 2000). The fact that gallic acid was present in only one of the five samples used in this study was somewhat surprising since it is one of the most common phenolic compounds in terrestrial plants (Fernandes & Salgado 2016). Kaempferol was only present in G. purpureum, ferulic acid was only present in L. stoechas spp.…”

Section: Antioxidant Activity Phenolic Profile and Trace Elementsmentioning

confidence: 74%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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Section: Antioxidant Activity Phenolic Profile and Trace Elementsmentioning

confidence: 74%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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“…Gallic acid is one of the most abundant phenolic acids. It has been isolated from different plant species such, but also is produced through the hydrolytic breakdown of tannic acid using a glycoprotein esterase [14].…”

Section: Gallic Acid As Plant-born Biologically Active Compoundmentioning

confidence: 99%

Plant Origin Phenolics as Prospective Antioxidants: State-of-Art for Application

Sahakyan¹,

Petrosyan²,

Batlutskaya³

et al. 2019

Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)

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In the recent years there is a growing demand for plant origin antioxidants, due to their potential therapeutic value and low level of side effects. Among the plant origin substances, the metabolites with antioxidant activity are the widely used which are mainly belong to the phenolic group of compounds as well as carotenoids and vitamins. These natural antioxidants act via different mechanisms: they can decrease the level of oxidative damage in cells directly reacting with free radicals or indirectly-by inhibition the activity and expression of free radical generating enzymes or enhancing the activity or expression of intracellular antioxidant defense enzymes. The manuscript is focused on the main group of phenolics which can be used in pharmacological, food and other areas.

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“…Галловая кислота является вторичным метаболитом, присутствующим в большинстве растений. Известно, что этот метаболит обладает рядом фармакологических свойств, включая антиоксидантные, противомикробные, противовоспалительные и противоопухолевые свойства [19].…”

Section: Introductionunclassified

Сerebroprotective effect of some phenolic acids under conditions of experimental brain ischemia

Voronkov

Поздняков

Нигарян

2020

Farm. farmakol. (Pâtigorsk)

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The aim of the study was to evaluate the cerebroprotective effect of some phenolic acids under the conditions of experimental cerebral ischemia in rats.Materials and methods. The experiment was conducted on male Wistar rats weighing 220–240 g. Focal cerebral ischemia was modeled by irreversible right-sided thermocoagulation of the middle cerebral artery under chloral hydrate anesthesia (350 mg/kg, intraperitoneally). The experimental compounds (4-hydroxy-3.5-di-tert-butyl cinnamic acid, caffeic acid and gallic acid 100 mg/kg each compound) and a reference drug (Mexicor – 100 mg/kg) were administered intragastrically next day after the surgery and then for three daysrunning. The effect of the test-compounds on the cognitive functions of the rats was evaluated by CRPA and TEA tests. The influence of the compounds on the changes in the concentration of lactate, pyruvate, homocysteine, as well as the degree of cerebral edema formation and necrosis of the brain tissue, were studied.Results. In the study, it has been established that against the background of the focal cerebral ischemia, the administration of caffeic, 4-hydroxy-3,5-di-tert-butylcinnamic and gallic acid, contributed to the preservation of a memorable trace in rats, as well as a decrease in lactate concentration (by 40.37% (p<0.05), 151.26% (p<0.05), 48.02% (p<0.05)) and pyruvate (by 96.6,% (p<0.05), 38, 78% (p<0.05), 33.3% (p<0.05)), homocysteine (by 59.6% (p<0.05), 102.18% (p<0.05), 28.8% (p<0.05)), аnecrosis zone (by 122.79% (p<0.05), 165.11% (p<0.05), 12.38% (p<0,05)) and cerebral edema (by 10.47% (p<0.05), 11.08% (p<0.05), 9.92% (p<0.05)) relative to the NC group of rats.Conclusion. The obtained data indicate the possibility of further detailed investigation of the cerebroprotective effect of 4-hydroxy-3,5-di-tert-butylcinnamic, caffeic and gallic acids.

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Gallic Acid: Review of the Methods of Determination and Quantification

Cited by 221 publications

References 73 publications

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Plant Origin Phenolics as Prospective Antioxidants: State-of-Art for Application

Сerebroprotective effect of some phenolic acids under conditions of experimental brain ischemia

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