Gallium-68 Prostate-Specific Membrane Antigen Positron Emission Tomography: A Practical Guide for Radiologists and Clinicians

Manzil, Fathima Fijula Palot; Kaur, Harleen; Szabados, Lajos

doi:10.7759/cureus.22917

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Previous studies report that age, surgical resection method, tumor pathological characteristics, thyroglobulin and recurrence risk stratification affect the therapeutic effect of 131 I therapy [7] [8] [9]. Low-dose 131 I treatment is less expensive and is associated with fewer side effects compared with high-dose 131 I treatment [10] [11] [12]. Therefore, it is imperative to administer effective treatment to patients with poor response, and avoid higher doses in people with good response to 131 I treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Zhou¹,

Cheng²

2023

JBM

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Objective: The purpose of this study was to investigate the effect of Hashimoto's thyroiditis on efficacy of 131 I ablation in intermediate-and high-risk of thyroid papillary carcinoma patients. The findings will help to develop a personalized treatment plan for patients with thyroid papillary carcinoma complicated with Hashimoto's thyroiditis. Material and Methods: From January 2016 to December 2020, patients who were diagnosed with intermediate-and high-risk PTC with lymph node metastasis were analyzed retrospectively, excluding patients with incomplete clinical data, distant metastasis, positive TGAb, TSH < 30 mIU/L. The baseline data of sex, age, and biochemical information were collected before admission. All patients included had radioactive iodine (RAI) with 3.70 GBq. The treatment response of patients was evaluated 6 -8 months after discharge. By means of univariate and multivariate analysis, including excellent response (ER) and non-excellent response (NER) groups of clinical data, we assessed the impact of 131 I on patients outcome. Results: A total of 525 patients (166 males and 359 females) were included in the study, including 368 patients in ER group (70.1%) and 157 patients in NER group (29.9%). Eleven factors including combining Hashimoto's thyroiditis, pre-ablative Tg levels, sex, tumor diameter, extraglandular invasion, multifocal, bilateral lesions, central lymph node metastasis, lateral lymph node metastasis, lymph node metastasis rate, thyroglobulin were statistically different between ER group and NER group with significance at P < 0.05. Further multivariate analysis showed that Hashimoto's thyroiditis, Ps-Tg levels and lateral lymph node metastasis could be used as independent factors. And patients with HT had significantly superior outcomes compared with patients without HT. Conclusion: Hashimoto's thyroiditis, Ps-Tg level and lateral lymph node metastasis are potential predictors for short-term efficacy of 131 I treatment in intermediate-and high-risk thyroid papillary carcinoma. Ha-How to cite this paper: Zhou, L. and Cheng, G. (2023) Effect of Hashimoto's Thyroiditis on Efficacy of 131 I Ablation Therapy in Intermediate-and High-Risk of Thyroid

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Section: Introductionmentioning

confidence: 99%

Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Zhou¹,

Cheng²

2023

JBM

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“…Amyloidosis is a group of uncommon conditions that result from the buildup of extracellular deposits of misfolded proteins as insoluble fibrils, leading to a gradual decline in the function of multiple organs and ultimately death [ 1 - 2 ]. The gold standard method for accurately diagnosing cardiac amyloidosis is an endomyocardial biopsy [ 3 ]. Advancements in cardiac imaging, diagnostic techniques, and treatments have enhanced the identification and management of cardiac amyloidosis in recent days [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Transthyretin Amyloidosis With Coincident Paget’s Disease: A Case Report

ALQattan,

Alqadhi,

AlKhamis

et al. 2023

Cureus

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Cardiac amyloidosis is a condition that results from the accumulation of amyloid proteins in the extracellular matrix of the myocardium. The diagnosis of this disease was challenging as it lacked distinct clinical symptoms and required a biopsy to confirm amyloid deposition. However, there is increasing evidence of non-invasive diagnostic criteria for cardiac amyloidosis, especially for the transthyretin (TTR) type. We report a case of a patient with both cardiac transthyretin amyloidosis (ATTR) and Paget's disease, and we highlight the various radiological features of these two conditions using hybrid imaging techniques. In addition, we discuss the diagnostic imaging characteristics of ATTR cardiac amyloidosis.

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Standardized template for clinical reporting of PSMA PET/CT scans

Esfahani,

Morris,

Sartor

et al. 2024

Eur J Nucl Med Mol Imaging

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Purpose Accurate diagnosis and staging of prostate cancer are crucial to improving patient care. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography with computed tomography (PET/CT) imaging has demonstrated superiority for initial staging and restaging in patients with prostate cancer. Referring physicians and PET/CT readers must agree on a consistent communication method and application of information derived from this imaging modality. While several guidelines have been published, a single PSMA PET/CT reporting template has yet to be widely adopted. Based on the consensus from community and academic physicians, we developed a standardized PSMA PET/CT reporting template for radiologists and nuclear medicine physicians to report and relay key imaging findings to referring physicians. The aim was to improve the quality, clarity, and utility of imaging results reporting to facilitate patient management decisions. Methods Based on community and expert consensus, we developed a standardized PSMA PET/CT reporting template to deliver key imaging findings to referring clinicians. Results Core category components proposed include a summary of any prior treatment history; presence, location, and degree of PSMA radiopharmaceutical uptake in primary and/or metastatic tumor(s), lesions with no uptake, and incidentally found lesions with positive uptake on PET/CT. Conclusions This article provides recommendations on best practices for standardized reporting of PSMA PET/CT imaging. The generated reporting template is a proposed supplement designed to educate and improve data communication between imaging experts and referring physicians.

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Gallium-68 Prostate-Specific Membrane Antigen Positron Emission Tomography: A Practical Guide for Radiologists and Clinicians

Cited by 3 publications

References 29 publications

Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Cardiac Transthyretin Amyloidosis With Coincident Paget’s Disease: A Case Report

Standardized template for clinical reporting of PSMA PET/CT scans

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Gallium-68 Prostate-Specific Membrane Antigen Positron Emission Tomography: A Practical Guide for Radiologists and Clinicians

Cited by 3 publications

References 29 publications

Effect of Hashimoto’s Thyroiditis on Efficacy of &lt;sup&gt;131&lt;/sup&gt;I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Effect of Hashimoto’s Thyroiditis on Efficacy of &lt;sup&gt;131&lt;/sup&gt;I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Cardiac Transthyretin Amyloidosis With Coincident Paget’s Disease: A Case Report

Standardized template for clinical reporting of PSMA PET/CT scans

Contact Info

Product

Resources

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Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma

Effect of Hashimoto’s Thyroiditis on Efficacy of <sup>131</sup>I Ablation Therapy in Intermediate- and High-Risk of Thyroid Papillary Carcinoma