Gallium(III) Iodide Mediated Mild and Efficient Method for Synthesis of 4-Iodotetrahydropyrans by Cross-Cyclization of Epoxides and Homoallylic Alcohols

Abstract

The synthesis of 4-iodotetrahydropyran derivatives has been achieved via gallium(III) iodide mediated cyclization of epoxides and homoallylic alcohols. This is a single step diastereoselective method for the preparation of 4-iodotetrahydropyrans.