Gallium(III) Ion Hydrolysis under Physiological Conditions

doi:10.5012/bkcs.2008.29.2.372

Cited by 36 publications

(3 citation statements)

References 23 publications

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“…These figures are reproduced based on reports of Sheha et al and Hacht (the yellow region is pH control range in the present work) for a better understanding. 62,63 Figure S8a,b suggest the redissolution of Co(OH) 2 and Ga(OH) 3 precipitates at high-pH regions of pH 7−11. However, compared to the reported distributions, almost all cobalt atoms were still in the solid precipitate at pH 7−11 as shown in Figure 12a in the present work.…”

Section: −mentioning

confidence: 99%

Supercritical Hydrothermal Synthesis of Spinel-Type Nonstoichiometric Cobalt Gallate Nanoparticles and Their Magnetic Properties

Xie

Numako

Naka

et al. 2023

Crystal Growth & Design

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Spinel-type metal oxide nanoparticles are known to exhibit various properties, which can be further enhanced by the synthesis of nonstoichiometric nanoparticles. In this work, we report the production of nonstoichiometric cobalt gallate nanoparticles (Co−Ga NPs) with larger inversion parameters that resulted in enhanced magnetic properties compared to previous studies. The synthesis of nonstoichiometric nanoparticles was realized by a supercritical hydrothermal process and without performing calcination at a high temperature which tended to synthesize thermodynamically stable stoichiometric products. We synthesized nonstoichiometric Co−Ga NPs with a controllable Co/Ga molar ratio, morphology, and particle size at different pH values of the precursor solutions. By applying X-ray absorption fine structure analysis at Ga K-edge, Co K-edge, and Rietveld refinement, nonstoichiometric Co−Ga NPs were found to have large numbers of cobalt atoms occupying octahedral sites compared to CoGa 2 O 4 . Their superparamagnetic behavior with enhanced spontaneous magnetization at room temperature owing to percolated superexchange interaction of J BB was observed for the first time. We also proposed a possible formation mechanism of nonstoichiometric Co−Ga NPs from cobalt gallium nitrate layered double hydroxides in the precursor solutions.

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Section: −mentioning

confidence: 99%

Supercritical Hydrothermal Synthesis of Spinel-Type Nonstoichiometric Cobalt Gallate Nanoparticles and Their Magnetic Properties

Xie

Numako

Naka

et al. 2023

Crystal Growth & Design

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“…At pH 8.5, gallium occurs as Ga(OH) 4 - . The stability constant of this complex is very low [27]. It can, therefore, be assumed that single hydroxide ligands might be substituted in favor of building a more stable complex.…”

Section: Resultsmentioning

confidence: 99%

Directed Evolution and Engineering of Gallium-Binding Phage Clones—A Preliminary Study

et al. 2019

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The phage surface display technology is a useful tool to screen and to extend the spectrum of metal-binding protein structures provided by nature. The directed evolution approach allows identifying specific peptide ligands for metals that are less abundant in the biosphere. Such peptides are attractive molecules in resource technology. For example, gallium-binding peptides could be applied to recover gallium from low concentrated industrial wastewater. In this study, we investigated the affinity and selectivity of five bacteriophage clones displaying different gallium-binding peptides towards gallium and arsenic in independent biosorption experiments. The displayed peptides were highly selective towards Ga3+ whereby long linear peptides showed a lower affinity and specificity than those with a more rigid structure. Cysteine scanning was performed to determine the relationship between secondary peptide structure and gallium sorption. By site-directed mutagenesis, the amino acids of a preselected peptide sequence are systematically replaced by cysteines. The resulting disulphide bridge considerably reduces the flexibility of linear peptides. Subsequent biosorption experiments carried out with the mutants obtained from cysteine scanning demonstrated, depending on the position of the cysteines in the peptide, either a considerable increase in the affinity of gallium compared to arsenic or an increase in the affinity for arsenic compared to gallium. This study shows the impressive effect on peptide–target interaction based on peptide structure and amino acid position and composition via the newly established systematic cysteine scanning approach.

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“…Despite the extensive potential medical applications of Ga, the progress to advance Ga-based compounds into clinical settings has largely been hindered by their low availability as they are extensively hydrolyzed to form insoluble hydroxide at physiological conditions. , Ga nitrate (Ganite), for example, is an FDA-approved drug for the treatment of cancer-related hypercalcemia. While this confirms the safety of Ga in clinical settings, a continuous 24 h a day intravenous infusion for 5–7 days is required for efficacy. , Formulating compounds into NPs has been shown to improve bioavailability and provide steady release of therapeutic agents. − As such, we hypothesized that formulating Ga into NPs will prolong and enhance their antimicrobial activity.…”

mentioning

confidence: 99%

Synthesis of Antimicrobial Gallium Nanoparticles Using the Hot Injection Method

Limantoro

Das

et al. 2023

ACS Mater. Au

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Antibiotic resistance continues to be an ongoing problem in global public health despite interventions to reduce antibiotic overuse. Furthermore, it threatens to undo the achievements and progress of modern medicine. To address these issues, the development of new alternative treatments is needed. Metallic nanoparticles have become an increasingly attractive alternative due to their unique physicochemical properties that allow for different applications and their various mechanisms of action. In this study, gallium nanoparticles (Ga NPs) were tested against several clinical strains of Pseudomonas aeruginosa (DFU53, 364077, and 365707) and multi-drug-resistant Acinetobacter baumannii (MRAB). The results showed that Ga NPs did not inhibit bacterial growth when tested against the bacterial strains using a broth microdilution assay, but they exhibited effects in biofilm production in P. aeruginosa DFU53. Furthermore, as captured by atomic force microscopy imaging, P. aeruginosa DFU53 and MRAB biofilms underwent morphological changes, appearing rough and irregular when they were treated with Ga NPs. Although Ga NPs did not affect planktonic bacterial growth, their effects on both biofilm formation and established biofilm demonstrate their potential role in the race to combat antibiotic resistance, especially in biofilm-related infections.

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Gallium(III) Ion Hydrolysis under Physiological Conditions

Cited by 36 publications

References 23 publications

Supercritical Hydrothermal Synthesis of Spinel-Type Nonstoichiometric Cobalt Gallate Nanoparticles and Their Magnetic Properties

Supercritical Hydrothermal Synthesis of Spinel-Type Nonstoichiometric Cobalt Gallate Nanoparticles and Their Magnetic Properties

Directed Evolution and Engineering of Gallium-Binding Phage Clones—A Preliminary Study

Synthesis of Antimicrobial Gallium Nanoparticles Using the Hot Injection Method

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