2007
DOI: 10.1111/j.1365-2796.2007.01783.x
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Gallstone disease

Abstract: Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk. Aetiology and pathogenesis of cholesterol gallstones still are not well defined, and strategies for prevention and efficient nonsurgical therapies are missing. This review summarizes current concepts on the pathogenesis of cholesterol gallstones with focus on the uptake and secretion of biliary lipids and special emphasis on recent… Show more

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Cited by 179 publications
(153 citation statements)
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References 197 publications
(171 reference statements)
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“…It is usually multifactorial in origin, and the etiology of this disease is related to a complex interaction of environmental and genetic factors (1)(2)(3). The worldwide prevalence rates range between 5% and 20%, but maybe as high as 70% in American Indian females.…”
Section: Introductionmentioning
confidence: 99%
“…It is usually multifactorial in origin, and the etiology of this disease is related to a complex interaction of environmental and genetic factors (1)(2)(3). The worldwide prevalence rates range between 5% and 20%, but maybe as high as 70% in American Indian females.…”
Section: Introductionmentioning
confidence: 99%
“…1 Prevalence rates based on ultrasound studies vary from 10%-15% in European adults to 3%-5% in African and Asian populations, while Indian figures have been reported as 3%-6%. 2,3 More than 80% of gallstone carriers are asymptomatic and it has been estimated that about 1%-2% of these develop complications and need surgery every year. 2 Complications of gallstone disease include acute and chronic cholecystitis, gallbladder perforation, choledocholithiasis with or without cholangitis, Mirizzi syndrome, cholecysto-enteric fistula, gallstone ileus and gallstone pancreatitis.…”
Section: Introductionmentioning
confidence: 99%
“…The pathogenesis of gallstone disease is suggested to be multifactorial and probably develops from complex interactions between many genetic and Sun H et al . Gender and metabolic differences of gallstone disease 1887 www.wjgnet.com environmental factors [12,13] . Because of an increase in the Westernization of dietary habits and a decrease in physical activity, the prevalence of gallstone disease has increased in the Chinese population in recent years.…”
Section: Introductionmentioning
confidence: 99%