Gallstone disease and related risk factors in a large cohort of diabetic patients

Pagliarulo, M.; Fornari, Fabio; Fraquelli, Mirella; Zoli, Marco; Giangregorio, F.; Grigolon, A.; Peracchi, M.; Conte, Dario

doi:10.1016/j.dld.2003.10.007

Cited by 84 publications

(80 citation statements)

References 23 publications

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“…The null effect of menopausal status is consistent with the results of previous studies (Pandey and Shukla, 2003;Pagliarulo et al, 2004); however, as the majority of our population was postmenopausal (92.5% controls), we had limited statistical power to assess risk among premenopausal women. In addition, the null effect of oral contraceptive (OC) use is consistent with the results of previous studies on biliary stones (Pagliarulo et al, 2004;Dhiman and Chawla, 2006) and biliary tract cancers (Milne and Vessey, 1991;Chow et al, 1994;Moerman et al, 1994), but the prevalence of OC use in the population is low (20% controls) and we lacked information on duration, composition, dose, and age of use.…”

Section: Discussionsupporting

confidence: 78%

“…In addition, the null effect of oral contraceptive (OC) use is consistent with the results of previous studies on biliary stones (Pagliarulo et al, 2004;Dhiman and Chawla, 2006) and biliary tract cancers (Milne and Vessey, 1991;Chow et al, 1994;Moerman et al, 1994), but the prevalence of OC use in the population is low (20% controls) and we lacked information on duration, composition, dose, and age of use. Furthermore, few subjects received hormone replacement therapy (2.4% controls), which has been associated with gallstones (Uhler et al, 2000;Simon et al, 2001;Chen et al, 2006) and gallbladder cancer (Gallus et al, 2002;Fernandez et al, 2003).…”

Section: Discussionsupporting

confidence: 71%

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Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

et al. 2010

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BACKGROUND: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. METHODS: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. RESULTS: The effects of parity (odds ratios, OR X3 vs 1 child ¼ 2.0, 95% confidence interval (CI) 0.7 -5.1), younger age at first birth (OR per 1-year decrease ¼ 1.2, 95% CI 0.99 -1.6), and older age at menarche (OR per 1-year increase ¼ 1.4, 95% CI 1.1 -1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. CONCLUSION: Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 71%

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

et al. 2010

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“…We must underscore that these figures were referred to the census overall population; so, the apparently increasing rates may have partially obeyed to the higher prevalence of T2DM in the population. However, we believe that having had access to precise estimations of the prevalence rates of T2DM from the Spanish Di@ (17). Moreover, other studies have reported similar crude incidence rates (18).…”

Section: Discussionmentioning

confidence: 99%

Tendencies and outcomes in endoscopic biliary sphincterotomies among people with or without type 2 diabetes mellitus in Spain, 2003-2013

et al. 2016

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We aimed to compare incidence and outcomes for endoscopic biliary sphincterotomies in people with or without type 2 diabetes mellitus (T2DM) in Spain (2003Spain ( -2013.We collected all cases of endoscopic biliary sphincterotomies using national hospital discharge data and evaluated annual incidence rates stratified by T2DM status. We analyzed trends over time for in-hospital mortality (IHM) as the primary outcome and a composite of IHM or procedure-related complications (key secondary outcome). In multivariate analyses, we tested T2DM as an independent factor of IHM and IHM or complications.We identified 126,885 endoscopic biliary sphincterotomies (23,002 [18.1%] in T2DM people). Crude incidence rates of endoscopic biliary sphincterotomies were > 3-fold higher in people with vs without T2DM (85.5/10 5 vs 26.9/10 5 population, respectively). Annual incidence rates of endoscopic biliary sphincterotomies showed 11-year relative increments of 77.5% (from 60.0 to 106.5/105) in T2DM, and 53.7% (from 21.6 to 33.2/105) in non-T2DM people (p < 0.001). We found no significant changes in mortality trends over time for the populations with or without T2DM (p = 0.15 and p = 0.21, respectively). Rates of procedural pancreatitis decreased in people without T2DM (p < 0.001). In the multivariate analysis, older age, higher comorbidity and endoscopic biliary sphincterotomy during urgent admission were associated with a higher IHM. T2DM was associated with a lower IHM after an endoscopic biliary sphincterotomy Further studies are needed to confirm a lower IHM for endoscopic biliary sphincterotomies in people with T2DM.

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“…As in other Western countries, obesity and closely associated type 2 diabetes are rapidly increasing in Finland (10,11). About 25% of diabetic patients have gallstone disease, and every fifth of the patients come into cholecystectomy (12). Long-term use of statins may be associated with decreased rate of cholelithiasis (13).…”

Section: Introductionmentioning

confidence: 99%

Declining Cholecystectomy Rate During the Era of Statin Use in Finland: A Population-Based Cohort Study Between 1995 and 2009

et al. 2013

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Gallstone disease and related risk factors in a large cohort of diabetic patients

Cited by 84 publications

References 23 publications

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

Tendencies and outcomes in endoscopic biliary sphincterotomies among people with or without type 2 diabetes mellitus in Spain, 2003-2013

Declining Cholecystectomy Rate During the Era of Statin Use in Finland: A Population-Based Cohort Study Between 1995 and 2009

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