1999
DOI: 10.1038/sj.ijo.0800781
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Gallstone disease risk in relation to body mass index and waist-to-hip ratio in Japanese men

Abstract: OBJECTIVE: To examine the relation of body mass index (BMI) and waist-to-hip ratio (WHR) to gallstones and postcholecystectomy risk in middle-aged Japanese men. DESIGN: Cross-sectional study. SUBJECTS: We used 174 men with prevalent gallstones, 104 with postcholecystectomy and 6909 with normal gallbladder in the consecutive series of 7637 men aged 48 ± 59 y receiving a preretirement health examination at four hospitals of the Japan Self-Defense Forces between 1986 and 1994. MEASUREMENTS: Gallbladder status was… Show more

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Cited by 32 publications
(17 citation statements)
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“… 1 In men, prevalence of gallstones is associated independently not only with BMI, but also with the waist‐to‐hip circumference ratio, which is an index of central adiposity. 2 In women, the prevalence of a self‐reported history of gallstone disease was also highest in the quartile with the highest waist‐to‐hip ratio, alongside with hypertension and diabetes. 3 These data are suggestive (although a clear‐cut relationship is still far from being established) of an association between gallstone disease in obesity and the metabolic syndrome linked to central adiposity, the cardinal feature of which is represented by hyperinsulinaemia.…”
Section: Introductionmentioning
confidence: 99%
“… 1 In men, prevalence of gallstones is associated independently not only with BMI, but also with the waist‐to‐hip circumference ratio, which is an index of central adiposity. 2 In women, the prevalence of a self‐reported history of gallstone disease was also highest in the quartile with the highest waist‐to‐hip ratio, alongside with hypertension and diabetes. 3 These data are suggestive (although a clear‐cut relationship is still far from being established) of an association between gallstone disease in obesity and the metabolic syndrome linked to central adiposity, the cardinal feature of which is represented by hyperinsulinaemia.…”
Section: Introductionmentioning
confidence: 99%
“…These factors are components of metabolic syndrome, which is a cluster of related conditions (i.e., abdominal obesity, high blood pressure, high plasma glucose, high triglycerides, and decreased high-density lipoprotein cholesterol (HDL); (Cowey and Hardy, 2006)). While individual components of metabolic syndrome have been linked to biliary tract cancers and biliary stones (Maclure et al , 1989; Kodama et al , 1999; Tsai et al , 2004; Andreotti et al , 2008; Seidell, 2010), the total effect of metabolic syndrome on these two conditions has not been investigated fully.…”
mentioning
confidence: 99%
“…High BMI is a crucial risk factor for some common cancers,26 but may not be a risk factor for prostate cancer. Some evidence indicates that BMI is positively associated with the incidence of gallstone disease,27–29 suggesting an important role in the relationship between history of cholelithiasis and the risk of prostate cancer. The HR was increased in the category of subjects with higher BMI (≥25 kg/m 2 ), indicating an intensified risk for the subjects with both history of cholelithiasis and higher BMI.…”
Section: Discussionmentioning
confidence: 99%