Gallstones in childhood: etiology, clinical features, and prognosis

Serdaroğlu, Filiz; Koca, Yavuz Savaş; Saltik, Fatma; Koca, Tuğba; Dereci, Selim; Akçam, Mustafa; Akçam, Füsun Zeynep

doi:10.1097/meg.0000000000000726

Cited by 32 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies regarding the prevalence of GS have reported a bimodal distribution with a small peak in infancy that increases throughout adolescence showing a marked female preponderance [ 5 11 12 ]. Boys and girls are equally affected during early childhood; however, a clear female preponderance observed during adolescence is similar to that observed in adulthood [ 3 5 11 13 ]. Mehta et al [ 5 ] reported an increase in the mean age of diagnosis of GS disease.…”

Section: Discussionmentioning

confidence: 67%

Cholecystectomy is Feasible in Children with Small-Sized or Large Numbers of Gallstones and in Those with Persistent Symptoms Despite Medical Treatment

Lee

Park

2020

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Purpose: We investigated the clinical features and factors affecting the choice of treatment modality and the course of pediatric gallstone (GS) disease. Methods: We retrospectively analyzed the medical records of 65 patients diagnosed with GS using imaging studies between January 2009 and December 2017 were included. Results: This study included 65 patients (33 boys and 32 girls; mean age, 8.5±5.3 years; range, 0.2-18 years) who primarily presented with abdominal pain (34%), jaundice (18%), and vomiting (8%). Idiopathic GS occurred in 36 patients (55.4%). The risk factors for GS included antibiotic use, obesity, hemolytic disease, and chemotherapy in 8 (12.3%), 7 (10.8%), 6 (9.2%), and 4 patients (6.2%), respectively. We observed multiple stones (including sandy stones) in 31 patients (47.7%), a single stone in 17 (26.2%), and several stones in 17 (26.2%). GS with a diameter of <5 mm occurred in 45 patients (69.2%). Comorbidities included hepatitis, choledocholithiasis, cholecystitis, and acute pancreatitis in 20 (30.8%), 11 (16.9%), 11 (16.9%), and 4 patients (6.2%), respectively. Ursodeoxycholic acid (UDCA) was administered to 54 patients (83.1%), leading to stone dissolution in 22 patients (33.8%) within 6 months. Cholecystectomy was performed in 18 patients (27.7%) (mean age, 11.9±5.1 years). Most patients treated surgically had multiple stones (83%) and stones measuring <5 mm in size (89%), and 66.7% of patients had cholesterol stones. Conclusion: Cholecystectomy is feasible in patients with small-sized or large numbers of GS and those with persistent abdominal pain and/or jaundice. UDCA administration with close follow-up is recommended in patients with uncomplicated GS.

show abstract

Section: Discussionmentioning

confidence: 67%

Cholecystectomy is Feasible in Children with Small-Sized or Large Numbers of Gallstones and in Those with Persistent Symptoms Despite Medical Treatment

Lee

Park

2020

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

“…UDKA tedavisinin safra kesesi taşı olan hastalarda, taşın çözünmesinde etkili olup olmadığı tartışmalı olsa da, semptomların hafifletilmesine yarar sağlayabileceği düşünülmektedir (22,23) . Çalışmamızda, Grup 2'de UDKA tedavisi alan hastalar ile semptomatik hastaların daha fazla olması bağlantılı olabilir.…”

Section: Discussionunclassified

Changing risk factors and surgical outcomes of cholecystectomy in children through the years: our 10-year experience

Demirel¹,

Hancıoğlu²,

Yağız³

et al. 2020

TCDD

View full text Add to dashboard Cite

show abstract

“…The rate of patients who did not have risk factors ranges between 23.2% and 52.5% in the literature (7,8,16). In the current study, we did not identify any risk factors in 36.1% of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for gallstones were searched regarding the studies of Gokce et al 7and Serdaroglu et al (8). Obesity, family history, ceftriaxone usage, staying in the intensive care unit, total parenteral nutrition (TPN) usage, diabetes, ileum resection, the presence of Down syndrome, and history of cardiac surgery were investigated as risk factors.…”

Section: Risk Factorsmentioning

confidence: 99%

Place of Cholecystectomy in Children with Uncomplicated Gallstones

et al. 2019

View full text Add to dashboard Cite

Background: The incidence of gallstones in children has increased in recent years. Risk factors that increase the formation of bile duct stones have been described in children, and discussions are ongoing about surgical indications of uncomplicated gallstones. Objectives: This study aimed to investigate the impact of risk factors on gallstone-induced complications and identify surgical indications for uncomplicated gallstones in children. Methods: Patients who had a cholecystectomy in the pediatric surgery clinic between October 2011 and January 2018 were evaluated. Data including age and sex, body mass index (BMI), associated risk factors, gallstone-induced complications, postoperative complications, postoperative complaints, and pathological results were recorded. Results: Seventy-two patients were included in the study. The mean age was 13.2 years with a female-to-male ratio of 2.27:1. Obesity was the most common risk factor (25%). A total of 44% of the patients experienced a complication on admission. The risk factors had no effect on the development of complications. The patients underwent cholecystectomy, but some symptoms persisted in thirteen patients postoperatively (18.1%). Ten of these patients did not have any risk factors; however, chronic cholecystitis findings were not identified in six specimens of those with uncomplicated gallstones. Conclusions: The risk factors have no influence on the development of gallstone-induced complications in children. Gallstones were cured with cholecystectomy; however, some complaints persisted in risk-free and uncomplicated gallstones. We think that if there are no risk factors in patients with uncomplicated gallstones, the patients should not receive surgery but be closely monitored.

show abstract

Gallstones in childhood: etiology, clinical features, and prognosis

Abstract: Our findings show that unknown causes are still prevalent in stone formation and that ursodeoxycholic acid exerts no effect on stone dissolution; however, diagnosis at younger than 2 years of age, a single stone, and small size of stone are factors affecting dissolution.

Cited by 32 publications

References 24 publications

Cholecystectomy is Feasible in Children with Small-Sized or Large Numbers of Gallstones and in Those with Persistent Symptoms Despite Medical Treatment

Cholecystectomy is Feasible in Children with Small-Sized or Large Numbers of Gallstones and in Those with Persistent Symptoms Despite Medical Treatment

Changing risk factors and surgical outcomes of cholecystectomy in children through the years: our 10-year experience

Place of Cholecystectomy in Children with Uncomplicated Gallstones

Contact Info

Product

Resources

About