Gallstones: The Present and Future of Medical Dissolution

Pearlman, B.J.; Schoenfield, Leslie J.

doi:10.1016/s0025-7125(16)31824-7

Cited by 8 publications

References 112 publications

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Cholelithiasis and carcinoma of the colon

Linos

O’Fallon

Thistle

et al. 1982

Cancer

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Cholelithiasis and carcinoma of the colon have similar geographic distributions and common dietary and chemical pathogenetic factors. A study was done to test whether an association between cholelithiasis and colonic cancer existed in the population of Rochester, Minnesota. During the period from 1950–1969, 2413 new cases of cholelithiasis were identified in this population. Because the age‐ and sex‐specific prevalence rates of colorectal cancer in this population were also available, the authors calculated the expected number of cases of colorectal cancer at the time of diagnosis of cholelithiasis. The relative risk (observed/expected) of colonic cancer among persons of all ages and both sexes with cholelithiasis was 1.52 (95% confidence interval, 1.1–2.0). Although the association seems significant, there is a potential bias in that the identification of asymptomatic cases of cholelithiasis might be facilitated in patients who have an operation or frequent follow‐up examinations for colonic cancer. When the analysis was repeated separately for symptomatic and asymptomatic cases of cholelithiasis, all the excess (and statistical significance) was confined to the asymptomatic group, an apparent confirmation of the suggested bias. Therefore, the authors believe that no real association exists between cholelithiasis and carcinoma of the colon.

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Cholelithiasis and carcinoma of the colon

Linos

O’Fallon

Thistle

et al. 1982

Cancer

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Drug and treatment efficacy of chenodeoxycholic acid in 97 patients with cholelithiasis and increased surgical risk

et al. 1983

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Patients with symptomatic cholelithiasis who represent higher than normal surgical risks may be the most suitable candidates for medical dissolution of gallstones. Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. Complete gallstone dissolution occurred in 27 of 97 patients (28%). If dropouts are excluded then the success rate is 27 of 64 patients (42%). Diarrhea was a common but manageable side effect for most. Thirty-two percent of patients developed chemical liver test abnormality; however, in only 13% was the degree of abnormality sufficient to require temporary (3%) or permanent (10%) cessation of therapy. Although better chemotherapeutic agents are needed, chenodeoxycholic acid is a reasonable choice for patients with non-calcified cholelithiasis in a functioning gallbladder if the patient is a heightened surgical risk. Because of the prolonged treatment period and the possibility of hepatotoxicity this treatment program requires a substantial commitment on the part of both the patient and the physician.

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Solubilization of multilamellar liposomes of egg yolk lecithin by the bile salt sodiumtaurodeoxycholate and the effect of cholesterol — a rapid-ultrafiltration study

Müller

Schuster

1990

Chemistry and Physics of Lipids

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Gallstones: The Present and Future of Medical Dissolution

Cited by 8 publications

References 112 publications

Cholelithiasis and carcinoma of the colon

Cholelithiasis and carcinoma of the colon

Drug and treatment efficacy of chenodeoxycholic acid in 97 patients with cholelithiasis and increased surgical risk

Solubilization of multilamellar liposomes of egg yolk lecithin by the bile salt sodiumtaurodeoxycholate and the effect of cholesterol — a rapid-ultrafiltration study

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