As a representative of the Renaissance, Dürer not only made significant contributions to the field of painting, such as portraiture, but also summarised the theories of art history, and he generously gave countless lessons to current and future generations. Dürer brought together the best of the art of Leonardo da Vinci and Michelangelo, among others, and combined it with his own style, making his work important to study. Dürer's Four Books on Human Proportion is a peak of art history theory, which contains many contents on the relationship between art and decoupage, which has an important impact on the study of the relationship between art and science in the Renaissance. This paper will provide some introduction to Dürer's biographical work and focus on the relationship between art and science as reflected in his focus on human proportions, which is an important guide to deconstruction and can be seen as a ground-breaking role. Dürer's focus on nature and his emphasis on artistic authenticity is why this work is worth studying.