2014
DOI: 10.1016/j.oraloncology.2014.02.003
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GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity

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Cited by 80 publications
(67 citation statements)
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“…RTK signaling is important for ovarian cancer progression [18], and RTK activity is regulated by O -glycosylation [13, 14, 20]. To evaluate the effect of GALNT6 knockdown on RTK activity, a human phospho-RTK array assay including 49 different RTKs was performed (Figure 3, left panel).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…RTK signaling is important for ovarian cancer progression [18], and RTK activity is regulated by O -glycosylation [13, 14, 20]. To evaluate the effect of GALNT6 knockdown on RTK activity, a human phospho-RTK array assay including 49 different RTKs was performed (Figure 3, left panel).…”
Section: Resultsmentioning
confidence: 99%
“…For example, dysregulation of GALNT1 contributes to the malignant progression of hepatocellular carcinoma by modifying glycosylation of the epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase (RTK) family [13]. GALNT2 contributes to malignant behaviors of oral squamous cell carcinoma [14]. GALNT6 modifies Mucin (MUC) 1 glycosylation and regulates proliferation of breast cancer cells [15] and is essential for O -glycosylation and stabilization of MUC4 of pancreatic cells [16].…”
Section: Introductionmentioning
confidence: 99%
“…The O-GalNAcylation of cell-surface receptors by GALNTs has been shown to regulate downstream signalling cascades203536. Since our data suggest that GALNT14 inhibits BMP signalling, we examined whether GALNT14 exerts this effect by the O-GalNAcylation of BMPRs.…”
Section: Resultsmentioning
confidence: 99%
“…However, the functional roles of GALNTs identified to date in cancer are mostly limited to their involvement in cancer cell motility or growth151718192021. Furthermore, the potential function of GALNTs on cancer progression, especially in site-specific metastasis, is poorly understood.…”
mentioning
confidence: 99%
“…GalNAc-T3 is revealed the independent predictor for reduced disease-free survival in early stage oral squamous cell carcinoma, and poor prognosis in renal cell carcinomas, respectively [21, 39], but indicated reduced invasive depth and good prognosis in lung adenocarcinoma and colon cancer [17, 31]. GalNAc-T2 enhanced migration and invasion of oral squamous cell carcinoma [25], but predicted favorable prognosis in neuroblastoma [26]. Up to now, there is no reasonable explanation and direct experiment for the contradictory influence of the individual GalNAc-T isoform in different cancers.…”
Section: Discussionmentioning
confidence: 99%