Galunisertib synergistically potentiates the doxorubicin-mediated antitumor effect and kickstarts the immune system against aggressive lymphoma

Rej, Abhinandan; Paladhi, Ankush; Daripa, Samrat; Sarkar, Debanjan; Bhattacharyya, Sankar; Mondal, Indrani; Hira, Sumit Kumar

doi:10.1016/j.intimp.2022.109521

Cited by 7 publications

(1 citation statement)

References 44 publications

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“…PIIO-1 reversed the exhaustion of T cells and overcame primary resistance to anti-PD-1 ICIs was demonstrated in recent study [ 51 ]. In aggressive B-cell non-Hodgkin lymphoma, galunisertib (TGF- β RI inhibitor) in combination with the chemotherapeutic agent doxorubicin exerted synergistic anticancer effects through preventing CD8 + T cells exhaustion [ 52 ]. In head and neck cancer, reversing exhausted CD8 + T cells via neutralizing TGF- β was one of the ways to improve the efficacy of neoadjuvant immunotherapy [ 53 ].…”

Section: Tgf- β Is Involved In the Formation Of Cd...mentioning

confidence: 99%

The role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells

Ma,

Sun,

Wang

2024

Clin Exp Med

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CD8 + T cells exert a critical role in eliminating cancers and chronic infections, and can provide long-term protective immunity. However, under the exposure of persistent antigen, CD8 + T cells can differentiate into terminally exhausted CD8 + T cells and lose the ability of immune surveillance and disease clearance. New insights into the molecular mechanisms of T-cell exhaustion suggest that it is a potential way to improve the efficacy of immunotherapy by restoring the function of exhausted CD8 + T cells. Transforming growth factor-β (TGF-β) is an important executor of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Recent studies have shown that TGF-β is one of the drivers for the development of exhausted CD8 + T cells. In this review, we summarized the role and mechanisms of TGF-β in the formation of exhausted CD8 + T cells and discussed ways to target those to ultimately enhance the efficacy of immunotherapy.

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Section: Tgf- β Is Involved In the Formation Of Cd...mentioning

confidence: 99%