Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3

Jiang, Nian; Li, Sanhua; Meng, Lingjie; Zhang, Yao; Yu, Changyan; Xiao, Yi; Liu, Yun

doi:10.1016/j.ejphar.2024.176372

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2024

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Cited by 4 publications

References 26 publications

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A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1

Zheng,

Xu,

Cai

et al. 2024

Phytomedicine

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A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1

Zheng,

Xu,

Cai

et al. 2024

Phytomedicine

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Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity

Meng,

Cao,

et al. 2024

Sci Rep

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Natural products, with their extensive chemical diversity, distinctive biological activities, and vast reservoirs, provide a robust foundation for advancing cancer therapeutics. A comprehensive phytochemical investigation of the skins from Bufo bufo gargarizans afforded two new bufadienolide derivatives identified as bufalactamides A and B ( 1–2 ), along with six known compounds: argentinogenin (3) , desacetylcinobufagin ( 4 ), desacetylcinobufaginol ( 5 ), cinobufaginol ( 6 ), bufalin ( 7 ) and gamabufalin ( 8 ). The structural elucidation of these compounds was meticulously carried out by analyses of spectroscopic data (1D and 2D NMR, HR-ESIMS), and comparison with the literature data. Plausible biosynthetic pathways for the new compounds were also discussed. Moreover, the cytotoxicity of the compounds was investigated using various cancer cell lines, including lung cancer (A549), colon cancer (HCT-116), liver cancer (SK-Hep-1), and ovarian cancer (SKOV3). Our research findings indicated that compounds 3 , and 6 – 8 exhibit potent cytotoxic activity (IC 50 < 2.5 µM). In contrast, compounds 4 and 5 display moderate cytotoxic activity (IC 50 < 50 µM) while compounds 1 and 2 show no cytotoxic activity (IC 50 > 100 µM). From this data, we conducted a comprehensive analysis of the structure-activity relationships among these compounds. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-79194-5.

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Multi-Omic Reveal that Gamabufotalin Exerts an Anti-Hepatocellular Carcinoma Effect by Regulation of Amino Acid Metabolism Via Targeting Stambpl1

Zheng,

Xu,

Cai

et al. 2024

Preprint

View full text Add to dashboard Cite

Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3

Cited by 4 publications

References 26 publications

A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1

A multi-omic analysis reveals that Gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1

Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity

Multi-Omic Reveal that Gamabufotalin Exerts an Anti-Hepatocellular Carcinoma Effect by Regulation of Amino Acid Metabolism Via Targeting Stambpl1

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