Coronavirus disease (Covid-19) is an infectious disease known as a severe acute respiratory syndrome. The first case of Covid-19 was identified in Wuhan, China on December 31, 2019. Health workers around the world are at the forefront of handling the COVID-19 pandemic. One of the health workers who is very important in handling COVID-19 cases is a nurse. The considerable increase of Covid-19 cases makes nurses have a heavier workload, struggle, and reduced rest periods. Heavy workloads and reduced rest periods can generally increase fatigue and affect sleep quality and stress levels which negatively impact work balance. This study's objective was to determine whether there was a relationship between the stress level and the quality of sleep of nurses in Jakarta during the Covid-19 pandemic. This study used 75 samples of nurses who were actively working during the Covid-19 pandemic in Jakarta, female, and aged 20-40 years. The sampling technique was snowball sampling. Data collection was through a questionnaire distributed via a Google form. The questionnaire included questions about the characteristics of the respondents, the Perceived Stress Scale (PSS-10), and the Pittsburgh Sleep Quality Index (PSQI). The study showed that there was a relationship between stress levels and the sleep quality of nurses in Jakarta during the Covid-19 pandemic.