Gambierol

Sasaki, Makoto; Cagide, Eva; Louzao, M. Carmen

doi:10.1002/9780470277874.ch1

Cited by 2 publications

References 83 publications

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Dinophyceae (Dinoflagellates)

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: General Aspects Classification of Dinoflagellates Photosynthetic Pigments Sulfated Exopolysaccharides Sterols Fatty Acids Glycolipids Amphidinols and other Polyhydroxylated Polyenic Derivatives Toxic Proliferations: Endotoxins and Exotoxins Main Types of Dinoflagellate Toxins Cyclic Polyethers Okadaic Acid and Derivatives Toxic Macrolides: Amphidinolides, Caribenolide, Goniodomin A , Hoffmanniolide Complexity of the Biosynthesis of Polyketides Saxitoxin and its Derivatives Nitrogenous Toxins with Imine Function Zooxanthellatoxins ( ZTs ) and other Nitrogenous Toxins Pfiesteria piscicida : A Particularly Toxic Dinoflagellate Sulfur‐Containing Derivatives Phosphorus Derivatives and other Unusual Compounds

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Dinophyceae (Dinoflagellates)

Kornprobst

2014

Encyclopedia of Marine Natural Products

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Calcium oscillations induced by gambierol in cerebellar granule cells

Albrecht¹,

Vale²,

Sasaki³

et al. 2010

J of Cellular Biochemistry

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Gambierol is a marine polyether ladder toxin derived from the dinoflagellate Gambierdiscus toxicus. To date, gambierol has been reported to act either as a partial agonist or as an antagonist of sodium channels or as a blocker of voltage-dependent potassium channels. In this work, we examined the cellular effect of gambierol on cytosolic calcium concentration, membrane potential and sodium and potassium membrane currents in primary cultures of cerebellar granule cells. We found that at concentrations ranging from 0.1 to 30 microM, gambierol-evoked [Ca(2+)]c oscillations that were dependent on the presence of extracellular calcium, irreversible and highly synchronous. Gambierol-evoked [Ca(2+)]c oscillations were completely eliminated by the NMDA receptor antagonist APV and by riluzole and delayed by CNQX. In addition, the K(+) channel blocker 4-aminopyridine (4-AP)-evoked cytosolic calcium oscillations in this neuronal system that were blocked by APV and delayed in the presence of CNQX. Electrophysiological recordings indicated that gambierol caused membrane potential oscillations, decreased inward sodium current amplitude and decreased also outward IA and IK current amplitude. The results presented here point to a common mechanism of action for gambierol and 4-AP and indicate that gambierol-induced oscillations in cerebellar neurons are most likely secondary to a blocking action of the toxin on voltage-dependent potassium channels and hyperpolarization of sodium current activation.

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Gambierol

Cited by 2 publications

References 83 publications

Dinophyceae (Dinoflagellates)

Dinophyceae (Dinoflagellates)

Calcium oscillations induced by gambierol in cerebellar granule cells

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