Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells

Gambogic Acid Induces G0/G1 Cell Cycle Arrest and Cell Migration Inhibition Via Suppressing PDGF Receptor β Tyrosine Phosphorylation and Rac1 Activity in Rat Aortic Smooth Muscle Cells

“…Previous studies have shown that GA can induce apoptosis in some tumor cells 13,33,34) . Our results suggested that the antiproliferative effect of GA was not due to apoptosis or necrosis (Fig.…”

“…Gambogic acid (GA, C38H44O8) is the major active compound of Gamboge, a brownish or orange resin exuded from the Garcinia hanburryi tree in Southeast Asia. Previous studies have demonstrated that GA has potent anticancer, anti-inflammatory activity and inhibits angiogenesis both in vivo and in vitro by suppressing the phosphorylation of AKT, ERK, c-Src, FAK and VEGFR2 [10][11][12][13][14][15] . However, the effects of GA on the proliferation and migration of VSMCs are not clearly understood.…”

Prenylated caged xanthones: Chemistry and biology

“…Gambogic acid (11) exhibits a potent proliferation inhibition by the G0/G1 phase cell cycle arrest and apoptosis induction in human lung adenocarcinoma A549 and human chronic myelogenous leukemia K562 cells, which might correlated with the downregulation of the expression of steroid receptor coactivator-3 (SRC-3), an important modulator of cell growth (Li et al, 2009a(Li et al, , 2009b. Gambogic acid (11) also inhibited the activity of Akt kinase and influenced the expression of the apoptosis related gene Bcl-2 in K562 cells (Li et al, 2009b).…”

“…Gambogic acid (11) also inhibited the activity of Akt kinase and influenced the expression of the apoptosis related gene Bcl-2 in K562 cells (Li et al, 2009b).…”

Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells

“…1,2 It is noteworthy that gambogic acid, a major ingredient isolated from the Chinese herb Gamboge hanburyi, can not only inhibit cell growth, induce apoptosis, and arrest the cell cycle in various carcinoma cell lines, including pulmonary carcinoma, 3 hepatocellular carcinoma, 4 breast cancer, 5 prostate cancer, 6 and gastric cancer, 7 but it can also inhibit tumor cell proliferation and inhibit angiogenesis by suppressing the phosphorylation of Akt, Erk, c-Src, Fak, and vascular endothelial growth factor receptor 2. 8,9 These findings suggest that gambogic acid may indeed be an effective agent in the treatment of cancer. However, to date, the potential mechanisms that account for the beneficial effects of gambogic acid remain largely unknown.…”