Gambogic Acid Inhibits Angiogenesis and Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2 Signaling

Yi, Tongxun; Yi, Zhengfang; Cho, Sung Gook; Luo, Jian; Pandey, Manoj K.; Aggarwal, Bharat B.; Liu, Mingyao

doi:10.1158/0008-5472.can-07-5944

Cited by 226 publications

(193 citation statements)

References 39 publications

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“…Conditioned medium from control adenovirus (dl312)-transduced MDA-MB-231 cells were able to induce tube formation of HCMECs within 18 h of incubation (Fig. 4A, a an b) as seen earlier (25,26). On the other hand, conditioned medium from AdMBP-1-transduced MDA-MB-231 cells significantly reduced tube formation (Fig.…”

Section: Resultssupporting

confidence: 70%

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice

et al. 2009

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Breast cancer is the leading cause of cancer death among women. We have shown previously an antiproliferative effect of MBP-1 on several human cancer cells. In this study, we have examined the potential of MBP-1 as a gene therapeutic candidate in regression of breast cancer growth and metastasis in an immunocompetent mouse model. For this, we have used a mouse breast cancer cell line (EO771) and syngeneic C57BL/6 mice. EO771 cells were implanted into the mammary fat pad of C57BL/6 mice. Replication-deficient recombinant adenovirus expressing MBP-1 was administered intratumorally to determine gene therapeutic potential. The results showed a significant regression of primary and distant (lung) tumor growth. Animals exhibited prolonged survival on treatment with MBP-1 compared with the control group (dl312). Subsequent studies suggested that MBP-1 inhibits matrix metalloproteinase expression in human breast cancer cells. Cells transduced with MBP-1 displayed inhibition of migration in a wound-healing assay. The conditioned medium from MBP-1-transduced cells blocked in vitro tube formation assay and inhibited expression of several angiogenic molecules. Taken together, our study shows that MBP-1 acts as a double-edged sword by inhibiting primary and metastatic tumor growth and modulating matrix metalloproteinase expression with a therapeutic potential against breast cancer progression. [Cancer Res 2009;69(24):9354-9]

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Section: Resultssupporting

confidence: 70%

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice

et al. 2009

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“…The transwell migration assay was carried out as described previously (Yi et al, 2008). Briefly, HUVECs were seeded onto transwell first, and after the cells were attached, the medium in the bottom chambers was changed to Dulbecco's modified Eagle's medium with or without VEGF.…”

Section: Methodsmentioning

confidence: 99%

RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma

et al. 2010

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“…Xenograft mouse model was used to evaluate the effect of oridonin tumor growth as described by Yi et al (Yi et al, 2008). The 5-week-old to 6-week-old severe combined immune deficiency (SCID) male mice (SLAC Laboratory Animal, China) weighing about 20g were divided into four groups with 6 animals for each group: control group, 5-FU group, oridonin high-dose treated group and oridonin lowdose treated group.…”

Section: Xenograft Mouse Modelmentioning

confidence: 99%

Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling

Xiao¹,

Chen²,

Qin³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway. Keywords

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Gambogic Acid Inhibits Angiogenesis and Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2 Signaling

Abstract: Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been previously reported to activate apoptosis in many types of cancer cell lines by targeting transferrin receptor and modulating nuclear factor-KB signaling pathway.

Cited by 226 publications

References 39 publications

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice

MBP-1 Inhibits Breast Cancer Growth and Metastasis in Immunocompetent Mice

RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma

Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling

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