Gambogic Acid Inhibits Proliferation of Human Lung Carcinoma SPC-A1 Cells in Vivo and in Vitro and Represses Telomerase Activity and Telomerase Reverse Transcriptase mRNA Expression in the Cells

Autophagy Inhibition Promotes Gambogic Acid-induced Suppression of Growth and Apoptosis in Glioblastoma Cells

“…The anticancer effects of Gambogic acid have been widely investigated in several types of cancer, including lung carcinoma, hepatocarcinoma, gastric carcinoma and so on (Wu et al, 2004;Zhao et al, 2004). GBM is the most common and aggressive primary brain cancer (Kleihues et al, 2002).…”

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

“…Cell Viability Assays Cell viabilities were measured by a colorimetric assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT; Roche, Ltd.) as described previously (22). Experiments were done in triplicate in a parallel manner for each concentration of GA used and the results were presented as mean F SE.…”

“…It has been shown that GA inhibited the growth of different types of cancer including hepatocarcinoma, gastric carcinoma, lung carcinoma, and breast cancer (21,22). Additionally, GA induced cancer cell G 2 -M phase arrest and repressed telomerase reverse transcriptase (23,24).…”

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

“…The resin has been used in traditional Chinese medicine for the treatment of cancers (15). It has potent anticancer activity because of its activation of the apoptotic pathways in cancerous cells (16)(17)(18)(19). Recently, it has been reported that GA triggers apoptosis upon binding to the transferrin receptor (20).…”