1995
DOI: 10.1002/bies.950171212
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Gamete and immune cell recognition revisited

Abstract: Fertilization is the result of a series of successful recognition and binding events mediated by gamete surface molecules. Recent advances in the identification and characterization of some of these recognition molecules provide extremely valuable information necessary to understand sperm-egg recognition and subsequent egg activation. We discuss these new data in the context of the model of gamete recognition first proposed by F.R. Lillie in the early part of the 20th century, and revisited periodically in the… Show more

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Cited by 8 publications
(6 citation statements)
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“…This finding implies that these kinases might play similar roles in both fertilization and immune-cell signaling events. This point of view was first hypothesized by Lillie (1913) and later revised by Belton and Foltz (1995). Although the functions of these kinases in egg activation remain largely unknown, the kinase profile described here should provide some useful information to study the possible signal transduction pathways involved in the fertilization event in the future.…”
Section: Comparative Analysis Of the Expression Pattern Of Aiei And Omentioning
confidence: 91%
“…This finding implies that these kinases might play similar roles in both fertilization and immune-cell signaling events. This point of view was first hypothesized by Lillie (1913) and later revised by Belton and Foltz (1995). Although the functions of these kinases in egg activation remain largely unknown, the kinase profile described here should provide some useful information to study the possible signal transduction pathways involved in the fertilization event in the future.…”
Section: Comparative Analysis Of the Expression Pattern Of Aiei And Omentioning
confidence: 91%
“…It is thought that similar principles may apply to membrane fusion events leading to sperm plasma membrane-oolemma adhesion and fusion. The responses of the oocyte following sperm-oocyte binding and fusion are strikingly similar to the responses that occur within lymphocytes following their activation by an antigen presenting cell (7). Based on this premise, numerous investigators have begun to dissect the relative contributions of various cell adhesion molecules in sperm-oocyte fusion as well as to implicate these molecules in specific defects, such as failure in IVF systems.…”
Section: Sperm-oocyte Fusionmentioning
confidence: 94%
“…Important signaling events also take place immediately after spermÀegg fusion to activate the egg, block polyspermy, and initiate development. The cellular events of egg activation have striking similarity to the responses that occur during T cell activation (Belton and Foltz, 1995). Like the na€ ıve T cell, unfertilized eggs are relatively quiescent cells arrested in a specific stage of the cell cycle.…”
Section: Signalingmentioning
confidence: 96%