Post-Traumatic Stress Disorder (PTSD) stands as a complex and pervasive mental health challenge, woven into the fabric of individual and collective experiences. The chapter sheds light into the heart of PTSD, seeking to understand its multifaceted origins, and intricacies of its development focussing on psychological, neurological, and sociological influences playing roles in shaping PTSD trajectory. It covers holistic understanding of PTSD, from the profound impact of trauma on brain's architecture to cultural and environmental factors amplifying its effects, laying the groundwork for subtle analysis of disorder. It stresses on importance of tailored-treatment approaches that address the unique needs of individuals. Traditional therapies like cognitive-behavioral and exposure therapies are scrutinized alongside pharmacological interventions and innovative modalities like technology-assisted, art, and nature-based interventions, including mind-body practices like yoga and meditation. Impact of community on PTSD treatment, emerging trends and research frontiers are also highlighted.