Gamitaeeumjowee-tang for Weight Loss in Post-Menopausal Obese Women: A Retrospective Chart Review

Abstract

Objectives: The purpose of this study is to evaluate weight change and analyze adverse events in post-menopausal obese women with <i>Gamitaeeumjowee-tang</i> for weight loss.Methods: A retrospective chart review was conducted for medical records of 115 post-menopausal obese women (body mass index, BMI≥25 kg/m<sup>2</sup>) who were administered with <i>Gamitaeeumjowee-tang</i> for 12 weeks for the purpose of weight loss. Weight, skeletal muscle ratio and BMI changes were compared before and after the program. Adverse events were evaluated by causality, severity and system-organ classes.Results: A total of 115 patients were included in this study. The average total weight loss in post-menopausal women was 5.72±2.04kg(p<0.001) and the average weight loss rate was 8.06±2.70%(p<0.001). After the 12-week program, the body fat rate was significantly decreased(3.76±2.20%)(p<0.001) and the skeletal muscle ratio was significantly increased(2.07±1.24%)(p<0.001). There were no significant differences in weight loss, skeletal muscle ratio change and body fat rate change depending on the number of hospital visits. Insomnia was frequently reported throughout the period, and no serious adverse events were reported.Conclusions: This study showed the potential that weight management treatment with <i>Gamitaeeumjowee-tang</i> could be a good way to lose weight of post-menopausal obese women without serious adverse events. Continuous well designed clinical studies are needed.