Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia

Soares, Karla Vanessa Souza; McGrath, John; Deeks, Jonathan J

doi:10.1002/14651858.cd000203

Cited by 39 publications

(20 citation statements)

References 36 publications

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“…Such findings are consistent with the degeneration of striatopallidal and striatonigral GABA-aminergic pathways that occur in response to antipsychotic therapy; however, human studies using GABA agonists have shown only minimal effects (42,43).…”

Section: Mechanisms Of Antipsychotic Induction Of Tdsupporting

confidence: 71%

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Tardive Dyskinesia in the Era of Typical and Atypical Antipsychotics. Part 1: Pathophysiology and Mechanisms of Induction

et al. 2005

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Section: Mechanisms Of Antipsychotic Induction Of Tdsupporting

confidence: 71%

“…The most prominent theory implicates postsynaptic dopamine receptor hypersensitivity. This model predicts that long-standing blockade of dopamine in the nigrostriatal pathway receptors leads to possibly permanent receptor hypersensitivity (Table 1) (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47).…”

Section: Mechanisms Of Antipsychotic Induction Of Tdmentioning

confidence: 99%

Tardive Dyskinesia in the Era of Typical and Atypical Antipsychotics. Part 1: Pathophysiology and Mechanisms of Induction

et al. 2005

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“…Ž Schapira, 2000andror GABA Coulthard et al, . 2000Soares et al, 2000 resulting from the higher dose of hypericum. However, as not all memory Ž tasks were impaired, and the choice reaction time a measure of attentional processing and a task that is sensitive to sedative effects; Hindmarch and Kerr, .…”

Section: Discussionmentioning

confidence: 99%

An investigation into the acute nootropic effects of Hypericum perforatum L. (St. Johnʼs Wort) in healthy human volunteers

Ellis

Stough

Vitetta

et al. 2001

Behavioral Pharmacology

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Hypericum perforatum L. (St. John's Wort) is a complex herb that has been used for centuries for its putative medicinal properties, and has current therapeutic relevance as a treatment of mild to moderate depression. Recently, two studies in rodents have suggested that hypericum may also have memory-enhancing effects. It has a complex pharmacology, in that acute administration modulates numerous neurotransmitter systems that have previously been observed to either augment or impair a variety of memory processes in humans. This study aimed to examine whether acute administration of standardized hypericum extract could exert a nootropic effect in normal human subjects. The study employed a double-blind, crossover, repeated-measures design. Twelve healthy young subjects completed the Cognitive Drug Research (CDR) memory battery, following administration of placebo, 900 mg and 1800 mg hypericum (Blackmore's Hyperiforte). The findings suggested that hypericum does not have an acute nootropic effect in healthy humans at these doses. However, there was some evidence for an impairing effect on accuracy of numeric working memory and delayed picture recognition at the higher dose. This observed impairment could be due to a sensitivity of these specific tasks to modulation by neurotransmitters that have been noted to have memory-impairing effects (e.g. y-aminobutyric acid (GABA), serotonin).

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“…TD is characterised by involuntary, repetitive and purposeless movements which commonly involve the oral and facial region as well as the trunk and extremities [1,2]. The pathophysiology of TD remains poorly elucidated, with prolonged blockade of postsynaptic dopamine receptors [1,3], dopaminergic hypersensitivity [4], GABA dysfunction [5] and cholinergic hypofunction [6] postulated as complementary mechanisms of action in the induction of TD.…”

Section: Introductionmentioning

confidence: 99%