Gamma-aminobutyric acid (GABA) increases in vitro germ-tube formation and phospholipase B1 mRNA expression in Candida albicans

Reyes-García, María Guadalupe; Hernández-Hernández, Francisca; García-Tamayo, F

doi:10.1007/s10267-011-0130-7

Cited by 13 publications

(7 citation statements)

References 25 publications

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“…radicle and hypocotyl used required nutrients from seeds, which did not involve in the process of allocating photosynthetic products. In addition, exogenous GABA, as an amino acid nitrogen fertilizer, would promote the growth of shoot and root of bud seedling [33]. Although this study indicates that the foliar application of GABA is direct and effective in deliver exogenous substances but more need to be done to determine the optimal GABA application protocol, including the formulation, total amount of usage, amount and concentration of a single use, timing, spraying intervals, and application methods, etc.…”

Section: Plos Onementioning

confidence: 89%

“…The different outcomes in terms of the fresh and dry weight of roots and aboveground parts from our study and Kaur and Zhawar’s may be due to that: 1) as a paddy crop, rice has strong tolerance against flooding and when exogenous GABA is used to alleviate salt stress, it does not need to allocate more photosynthetic products for roots to grow and function normally; 2) that Kaur and Zhawar [ 32 ] used seedlings at the bud stage during which rapidly elongated rice radicle and hypocotyl used required nutrients from seeds, which did not involve in the process of allocating photosynthetic products. In addition, exogenous GABA, as an amino acid nitrogen fertilizer, would promote the growth of shoot and root of bud seedling [ 33 ]. Although this study indicates that the foliar application of GABA is direct and effective in deliver exogenous substances but more need to be done to determine the optimal GABA application protocol, including the formulation, total amount of usage, amount and concentration of a single use, timing, spraying intervals, and application methods, etc.…”

Section: Discussionmentioning

confidence: 99%

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Effects of foliage-applied exogenous γ-aminobutyric acid on seedling growth of two rice varieties under salt stress

et al. 2023

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Exogenous γ-aminobutyric acid (GABA) has been used and regarded as a potential enhancer for plant resistance against various biotic or abiotic attackers in the crop production, especially as a promising alleviator against salt stress. In order to determine whether GABA is truly effective in promoting rice resistance under a certain level of salt stress or not and to evaluate its effect on the growth and some physiological responses of two Japonica rice varieties under salt stress. 3-leaf rice seedlings germinated from seeds were cultivated in a separate hydroponic cup with a nutrient solution that was salinized with 0, 25, 50, or 75 mmol K+ of NaCl. A 4 mmol L−1 GABA solution or water were sprayed onto leaves once a day for 8 days prior to an assessment of the seedling growth, the growth indices, root activities and three antioxidant enzyme activities in leaves were measured. Data analyses indicated that as the salt concentration increased, the plant height and the leaf area of both rice varieties decreased, while the dead leaf rate, weight ratio of the dry- and fresh-roots, superoxide dismutase (SOD) and peroxidase (POD) activities increased. Under the same saline conditions, the root activities and the leaf ascorbate peroxidase (APX) activity were enhanced at a low NaCl concentration but reduced when the salt concentration was high. A foliar application of GABA daily on both rice varieties for over a week under 3 different salinized treatments as compared with the corresponding treatments sprayed with water resulted in an enhanced effect on plant height increment by 1.7-32.4%, a reduction of dead leaf rate by 1.6-36.4%, a decline of root dry weight by 9.3-30.9% respectively, and an increment in root activities by 8.1-114.5%, and POD, SOD and APX enzyme activities increased by 5.0-33.3%, 4.1-18.5%, and 7.2-64.4% respectively. However, two rice varieties showed a significant difference in response to various salinized levels. Overall results of this study demonstrate that the application of exogenous GABA on the leaves of rice seedlings under salt stress has improved rice salt tolerance, which should provide a sufficient information for ultimately making it possible to grow rice in salinized soil.

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Section: Plos Onementioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Effects of foliage-applied exogenous γ-aminobutyric acid on seedling growth of two rice varieties under salt stress

et al. 2023

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“…Conversely, neuromediators may have an impact on gut fungi. For example, gamma-aminobutyric acid (GABA) is able to increase virulence and germ tube formation of C. albicans [ 56 ], while serotonin attenuates the C. albicans virulence [ 57 ].…”

Section: Mycobiome Interactions Within the Gut Ecosystemmentioning

confidence: 99%

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

et al. 2018

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In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.

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“…Aminobutyrate is related to the gamma-aminobutyric acid (GABA) and it can be also used for succinate synthesis 38 . These metabolites can also be related to the virulence because GABA increases in vitro germ-tube formation and phospholipase B1 expression in C. albicans 39 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of Candida clinical isolates of different species and infection sources

Oliver

Laghi

Parolin

et al. 2020

Sci Rep

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Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characterize clinical isolates of Candida spp. by proteomics (MALDI-TOF MS) and metabolomics (1H-NMR), and to correlate their metabolic profiles with Candida species, source of infection and different virulence associated parameters. In particular, 49 Candida strains from different sources (blood, n = 15; vagina, n = 18; respiratory tract, n = 16), belonging mainly to C. albicans complex (61%), C. glabrata (20%) and C. parapsilosis (12%) species were used. Several extracellular and intracellular metabolites showed significantly different concentrations among isolates recovered from different sources of infection, as well as among different Candida species. These metabolites were mainly related to the glycolysis or gluconeogenesis, tricarboxylic acid cycle, nucleic acid synthesis and amino acid and lipid metabolism. Moreover, we found specific metabolic fingerprints associated with the ability to form biofilm, the antifungal resistance (i.e. caspofungin and fluconazole) and the production of secreted aspartyl proteinase. In conclusion, 1H-NMR-based metabolomics can be useful to deepen Candida spp. virulence and pathogenicity properties.

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Gamma-aminobutyric acid (GABA) increases in vitro germ-tube formation and phospholipase B1 mRNA expression in Candida albicans

Cited by 13 publications

References 25 publications

Effects of foliage-applied exogenous γ-aminobutyric acid on seedling growth of two rice varieties under salt stress

Effects of foliage-applied exogenous γ-aminobutyric acid on seedling growth of two rice varieties under salt stress

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

Metabolic profiling of Candida clinical isolates of different species and infection sources

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