Gamma-Aminobutyric Acid Neuropharmacological Investigations on Narcosis Produced by Nitrogen, Argon, or Nitrous Oxide

Abraini, Jacques H.; Kriem, Badreddine; Balon, Norbert; Rostain, Jean-Claude; Risso, Jean-Jacques

doi:10.1213/01.ane.0000050282.14291.38

Cited by 80 publications

(57 citation statements)

References 13 publications

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“…This was not the case after pretreatment with a GABA B -receptor antagonist. Thus—similar to nitrogen—involvement of GABA A - and the benzodiazepine site of GABA A -receptors, but none of GABA B -receptors, was hypothesized [26]. However, this finding is limited by the fact that Abraini and colleagues used the (hyperbaric) narcotic properties of argon as outcome parameter.…”

Section: Discussionmentioning

confidence: 99%

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

Höllig

Schug

Fahlenkamp

et al. 2014

IJMS

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Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in vitro models for ischemic pathologies to investigate the effect of argon treatment. Promising data has been published concerning pathologies like cerebral ischemia, traumatic brain injury and hypoxic ischemic encephalopathy. However, models applied and administration of the therapeutic gas vary. Here we provide a systematic review to summarize the available data on argon’s neuro- and organoprotective effects and discuss its possible mechanism of action. We aim to provide a summary to allow further studies with a more homogeneous setting to investigate possible clinical applications of argon.

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Section: Discussionmentioning

confidence: 99%

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

Höllig

Schug

Fahlenkamp

et al. 2014

IJMS

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show abstract

“…Xenon is known to antagonize NMDA receptors (33) and activate ATP-sensitive potassium channels (34) and the two-pore potassium channels (35). Argon may effect, gamma-aminobutyric acid type-A receptors (GABA) though further data is required to assess whether this is the mechanism for cytoprotection (36). Similarly the mechanisms of helium-induced organ-protection remain unclear.…”

Section: Discussionmentioning

confidence: 99%

The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*

Zhuang

Yang

Zhao

et al. 2012

Critical Care Medicine

126

130

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Abstract:OBJECTIVE: Xenon provides neuroprotection in multiple animal models however little is known about the other noble gases. The aim of the current study was to compare xenon, argon and helium neuroprotection in a neonatal asphyxia model in MEASUREMENTS AND MAIN RESULTS: Control animals undergoing moderatehypoxic-ischemia endured reduced neuronal survival at 7 days with impaired neurological function at the juvenile age compared with naïve animals. Severe hypoxic-ischemic damage produced a large cerebral infarction in controls. Following moderate hypoxic-ischemia, all three noble gases improved cell survival, brain structural integrity and neurological function on post-natal day 40 compared to nitrogen. Interestingly argon improved cell survival to naïve levels while xenon and helium did not. When tested against more severe hypoxic-ischemic injury only, argon and xenon reduced infarct volume. Furthermore post-injury body weight in moderate insult was lower in the helium treated group compared to the naïve, control and other noble gas treatment groups while in severe injurious setting it is lower in both control and helium treated group than other groups. In the non-directly injured hemisphere argon, helium and xenon increased the expression of Bcl-2 while helium 4 and xenon increased Bcl-xL. In addition, Bax expression was enhanced in the control and helium groups.CONCLUSIONS: These studies indicate that argon and xenon provide neuroprotection against both moderate and severe hypoxia-ischemic brain injury likely via prosurvival proteins synthesis.

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“…(2) Abraini et al (2003) found that Ar may directly act at the c-aminobutyric acid (GABA) receptor by potentiating the subtype GABA A neurotransmission. GABA reduces the activating firing rate of IHC afferents mediated by the GABA A receptor subtype .…”

Section: Discussionmentioning

confidence: 99%

Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in the newborn rat’s organ of Corti

et al. 2005

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Gamma-Aminobutyric Acid Neuropharmacological Investigations on Narcosis Produced by Nitrogen, Argon, or Nitrous Oxide

Cited by 80 publications

References 13 publications

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*

Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in the newborn rat’s organ of Corti

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