Gamma-Glutamyl Transpeptidase as the Marker of Kidney Graft Function

Abstract

Background. Gamma-glutamyl transpeptidase (GGT) is a glycoprotein of the external surface of various cell types. The activity of GGT has been observed in cells and tissues with secretory activity, such as the proximal tubular cells in kidneys. GGT also plays an important pro-oxidant role, stimulating the generation of hydroxyl radicals, and increases membrane lipid peroxidation. Objectives. In this study we examined whether the monitoring of GGT activity in urine may be a prognostic factor of kidney allograft function. The study enrolled 107 Caucasian renal transplant recipients. Material and Methods. Urine samples were collected for GGT and creatinine analysis on the 1 st day after transplantation, and then in the 3 rd and 12 th month. Results. Higher urine GGT activity in the 3 rd month after transplantation was associated with significantly higher risk of graft failure (HR = 1.063 per each U/g creatinine; 95%Cl:1.004-1.127; p = 0.037) in the Cox proportional hazards model. Moreover, there were positive correlations between urine GGT and the grade of interstitial fibrosis (Rs = 0.64, p = 0.01) and tubular atrophy (Rs = 0.54, p = 0.056) in specimens collected in the 3 rd month after transplantation. Conclusions. Our results suggest that higher urine GGT activity in the 3 rd month after transplantation may be a prognostic factor of graft failure (Adv Clin Exp Med 2014, 23, 6, 947-952).

Volatile Oil of Croton Zehntneri Per Oral Sub-Acute Treatment Offers Small Toxicity: Perspective of Therapeutic Use

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Ameliorative Effects of Vanadyl Sulfate on Some Biochemical Parameters of Experimental Diabetic Rat Kidneys

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Diagnostic Approach to Nephrotoxicosis with Vitamin K3 in Draft Horses Based on iNOS and Selective Urinary Variables

“…The observed renal damage caused by menadione resulted in azotemia, proteinuria, hematuria, glucosuria and elevated serum creatinine, gamma-glutamyl transferase enzyme activity which is a glycoprotein observed in cells with secretory function, such as the proximal renal tubular cells. It has pro-oxidant activity by modulation of hydroxyl radicals' production and increasing the membrane lipid peroxidation (Kwiatkowska et al, 2014). There is a great relationship between body electrolyte balance and renal function.…”