Gamma-glutamyl transpeptidase–platelet ratio, systemic immune inflammation index, and system inflammation response index in invasive Aspergillosis

Abstract

OBJECTIVE: Gamma-glutamyl transpeptidase-platelet ratio, system inflammation response index, and systemic immune inflammation index are three systemic immune and inflammation indexes that were investigated for their diagnostic and prognostic proficiencies in cardiovascular diseases and cancers. However, their predictive values for invasive aspergillosis have not yet been studied. The aim of this study was to evaluate Gamma-glutamyl transpeptidase-platelet ratio, system inflammation response index, and systemic immune inflammation index levels and their diagnostic values in invasive aspergillosis.METHODS: A total of 23 patients with invasive aspergillosis and 23 sex-and age-matched healthy participants were included in this study. Complete blood count parameters and liver function tests were studied. Gamma-glutamyl transpeptidase-platelet ratio, system inflammation response index, and systemic immune inflammation index were calculated.RESULTS: Leukocyte, neutrophil, lymphocyte, and monocyte levels were statistically significantly higher in IA group (p=0.031, p=0.027, p=0.033, and p=0.001, respectively). In invasive aspergillosis group, platelets were numerically lower; Aspartate transaminase, alanine aminotransferase, and lactic dehydrogenase levels were numerically higher than those in control group but differences between levels were not statistically significant (p>0.05). The γ-glutamyl transpeptidase levels of patients were statistically significantly higher (p=0.007), and in addition, statistically significant differences were found between groups in terms of gamma-glutamyl transpeptidase-platelet ratio, system inflammation response index, and systemic immune inflammation index (p<0.001, p=0.037, p=0.001, respectively).Receiver operating characteristic analysis was performed, and areas under the curves were evaluated. gamma-glutamyl transpeptidaseplatelet ratio had the higher area under the curve than systemic immune inflammation index and system inflammation response index (AUC 0.849, 0.798, 0.693, respectively). The results from receiver operating characteristic analysis of the data suggested that the use of a cutoff value of 0.15 for gamma-glutamyl transpeptidase-platelet ratio would be optimum for clinical use to confirm independent predictors of patients with invasive aspergillosis.CONCLUSIONS: Gamma-glutamyl transpeptidase-platelet ratio is an independent, a useful predictor, and is superior to other evaluated markers in the diagnosis of inflammation in invasive aspergillosis. Gamma-glutamyl transpeptidase-platelet ratio may also be a helpful biomarker for clinicians to follow-up the inflammatory process of these patients.

Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior

“…SII and SIRI are new biomarkers studied to predict the prognosis of numerous neurological and cardiac diseases, especially in cancers [16][17][18][19][20][30][31][32][33]. The fact that inflammation is a pathological mechanism in psychiatric diseases has led researchers to investigate these two biomarkers [34].…”

“…SIRI is a new biomarker of inflammation based on neutrophil, lymphocyte, and monocyte counts. Like SII, SIRI has been extensively studied in physical diseases such as tumors, cardiovascular diseases, and stroke [18][19][20]. However, there are limited studies examining SIRI values in patients with BD.…”

“…Neutrophil, monocyte, and lymphocyte counts, which are effective for determining the relationship between inflammation and immune response, have been used to calculate the systemic inflammatory response index (SIRI). Reportedly, SIRI can be used as an indicator of poor prognosis in cancer, and it better predicts the benefit of treatment [19,20]. These two indices reflect the interaction between inflammation, thrombocytosis, and the immune response.…”

Sistemik Lupus Eritematozus Hastalarında İnflamasyon Belirteci ve Yüksek Hastalık Aktivite Göstergesi Olarak Yeni Hematolojik İndeksler

“…SİYİ, kanser, bulaşıcı hastalıklar ve kardiyovasküler hastalık gibi hastalıklarda anlamlı olarak yüksek bulunmuştur. [34][35][36][37] SİAİ, idiyopatik pulmoner fibroziste pognostik faktör olarak saptanmıştır. 38 SİAİ, SİYİ ve Sİİ indekslerinin COVİD-19 enfeksiyonlarında hastalığın ciddiyetini ve yoğun bakım ihtiyacını göstermede kullanılabileceği gösterilmiştir.…”

The role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disorders

“…Описаны различные маркеры и субстраты воспалительных реакций в центральной нервной системе (ЦНС) при биполярном аффективном расстройстве (БАР), включающие в частности нейромедиаторные системы, цитокины, а также структурные изменения вещества головного мозга [5]. Прогностическая значимость индекса системного иммунного воспаления (systemic immuneinflammation index, SII) и индекса системной воспалительной реакции (system inflammation response index, SIRI) доказана при различных соматических заболеваниях [8], однако в контексте психических расстройств освещена недостаточно широко. Имеются данные о взаимосвязи между SII и депрессией у мужчин, больных сахарным диабетом [37],…”