Gamma-Glutamyltransferase and Risk of Acute Coronary Syndrome in Young Chinese Patients: A Case-Control Study

Huang, Yuli; Luo, Jianjin; Liu, Xinyue; Wu, Yu; Yang, Yingkui; Li, Wensheng; Lv, Weibiao; Hu, Yunzhao

doi:10.1155/2018/2429160

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Serum GGT is a widely used marker for fatty liver disease and alcohol consumption and is associated with an increased risk of CAD [29]. Huang et al reported that GGT was associated with the risk of ACS in relatively young patients [8]. In the current study, GGT was associated with CAD in young patients according to the Mann-Whitney U test, but not significantly associated with CAD by univariate analysis.…”

Section: Discussioncontrasting

confidence: 42%

“…In order to provide earlier and better diagnosis of CAD in young adults, novel risk factors and markers have been evaluated in the literature [6][7][8]. However, these studies included specific cohorts, such as ACS [6][7][8][9]. Therefore, we aimed to investigate the relationship between traditional and nontraditional risk factors and the presence of significant atherosclerosis in a young population with SAP.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for coronary artery disease in young patients with stable angina pectoris

Duran¹,

Elçik²,

Murat³

et al. 2019

Turk J Med Sci

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Background/aim: We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP). Materials and methods:A total of 571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the control group consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors of these two groups in terms of the presence of CAD.Results: Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabetes were similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin, and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoprotein cholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels, older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors for the presence of CAD in young patients. Conclusion:Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict the presence of CAD in a young population with SAP.

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Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Risk factors for coronary artery disease in young patients with stable angina pectoris

Duran¹,

Elçik²,

Murat³

et al. 2019

Turk J Med Sci

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“…More importantly, they demonstrated in multivariate analysis that serum GGT activity was an independent predictor of in-hospital MACE (odds ratio (OR) 1.12, 95% confidence interval (CI) 1.01-1.33; p < 0.001) [32]. These results agree with those of others who confirmed the prognostic value of GGT in long-term follow-up [33,34].…”

Section: Discussionsupporting

confidence: 79%

Serum Gamma Glutamyltransferase Is Associated with 25-Hydroxyvitamin D Status in Elderly Patients with Stable Coronary Artery Disease

Danikiewicz

Hudzik

Nowak

et al. 2020

IJERPH

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Background: No previous study has investigated the association between gamma glutamyltransferase (GGT) and vitamin D in patients with stable coronary artery disease (CAD). We investigated the cross-sectional associations between vitamin D status as assessed by serum 25(OH)D and GGT. Methods: 169 patients were enrolled. Study population was divided into three groups: 1: 25(OH)D < 10 ng/mL (n = 59); 2: 25(OH)D 10–20 ng/mL (n = 82), and 3: 25(OH)D > 20 ng/mL (n = 28). Based on a cut-off GGT value identified in ROC analysis, we also divided the study population to compare the following groups: GGT ≤19 (n = 66) and GGT >19 (n = 103). Results: GGT activity was the highest in vitamin D severely deficient patients and the lowest in vitamin D insufficient patients. GGT was inversely correlated with 25(OH)D concentrations (R = −0.23; p = 0.002). The receiver operating characteristics curve identified the discrimination threshold of GGT of >19 U/L in predicting vitamin D deficiency. Higher leukocyte and neutrophil counts and lower 25(OH)D concentration were found in patients with GGT > 19 U/L. Conclusions: We identified an interaction between declining 25(OH)D levels and rising GGT levels with increasing age, which resulted in an unfavorable 25(OH)D-to-GGT ratio in stable CAD patients. These results suggest that these changes might further contribute to a high cardiovascular risk in the elderly.

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“…Hemoglobin, FBG, HbA 1c , total cholesterol (TC), triglycerides, low-density lipoprotein-C (LDL-C), high-density lipoprotein cholesterol, serum creatinine, highsensitivity C-reactive protein (hs-CRP), and N-terminal pro-Btype natriuretic peptide (NT-proBNP) levels were detected. LDL-C was calculated using the Friedewald equation (17,18). TyG index was calculated using the following: Ln [fasting triglycerides (mg/dL) × FBG (mg/dL)/2] (5).…”

Section: Baseline Characteristics Tyg Index Detection and Cmr Examinationmentioning

confidence: 99%

Triglyceride–Glucose Index and Extracellular Volume Fraction in Patients With Heart Failure

Yang

Liu

et al. 2021

Front. Cardiovasc. Med.

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Background: The triglyceride–glucose (TyG) index had been proposed as a reliable surrogate marker of insulin resistance. We aimed to evaluate the association between TyG index and myocardial fibrosis, which was quantified by extracellular volume (ECV) fraction using cardiovascular magnetic resonance (CMR) examination, and their prognostic value in patients with heart failure (HF).Methods: In this retrospective cohort study, 103 hospitalized HF patients were included. ECV fraction was calculated using CMR measurements and T1 mapping. TyG index was calculated using fasting triglyceride and blood glucose. The primary outcome events were defined as all-cause mortality and HF hospitalization during follow-up.Results: During the median follow-up of 12.3 months, 39 patients (37.9%) experienced primary outcome events and had higher levels of TyG index, N-terminal pro–B-type natriuretic peptide (NT-proBNP), and ECV fraction compared with those without events. Multivariate linear regression analysis showed that the TyG index was the significant factor determined for ECV fraction (rpartial = 0.36, P = 0.01). In multivariate Cox regression analysis, presence of diabetes [hazard ratio (HR) = 1.28, 95% confidence interval (CI) = 1.01–1.62], higher TyG index (HR = 2.01, 95% CI = 1.03–4.01), ECV fraction (HR = 1.73, 95% CI = 1.04–2.88), and NT-proBNP (HR = 2.13, 95% CI = 1.08–4.20) were independent risk factors for the primary outcome events.Conclusions: TyG index is a novel biomarker of myocardial fibrosis in HF patients and can be considered as a useful risk stratification metric in the management of HF.

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Gamma-Glutamyltransferase and Risk of Acute Coronary Syndrome in Young Chinese Patients: A Case-Control Study

Cited by 13 publications

References 31 publications

Risk factors for coronary artery disease in young patients with stable angina pectoris

Risk factors for coronary artery disease in young patients with stable angina pectoris

Serum Gamma Glutamyltransferase Is Associated with 25-Hydroxyvitamin D Status in Elderly Patients with Stable Coronary Artery Disease

Triglyceride–Glucose Index and Extracellular Volume Fraction in Patients With Heart Failure

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