Gamma-glutamyltransferase as a preoperative differential diagnostic marker in patients with adnexal mass

Defining Models to Classify between Benign and Malignant Adnexal Masses Using Routine Laboratory Parameters

“…Additionally, in other already available predicting scores, the combination of parameters improved the discrimination of adnexal masses [30,31]. Compared to a variety of biomarker studies [12][13][14]32], these new models are applicable in a routine setting, as only routinely available parameters were included in the model building process. Besides classic laboratory parameters, patient age was included as a clinical parameter as to be found also in other classifiers such as the Copenhagen index (CA125, HE-4, and age) [31].…”

“…In the search for other predictive serum markers, preoperative hypoalbuminemia was described as a prognostic parameter in ovarian cancer [9] and other gynecologic malignancies [10,11]. Likewise, C-reactive protein (CRP), gamma glutamyl transferase (GGT), and lactate dehydrogenase (LDH) were identified to be promising in the differential diagnosis of adnexal masses [12][13][14], whereby CRP seems to have a stronger predictive potential with a sensitivity and specificity of 80.1% and 90.8%, respectively, in combination with CA125, whereas GGT showed a sensitivity and specificity of 54.5% and 83.8%. A variety of biomarker panels has been proposed, but none have been comprehensively used in clinical routine thus far.…”