Gamma-glutamyltransferase, possible novel biomarker in colon diverticulosis: a case-control study

Abstract

The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by the excessive consumption of alcoholic or cholesterol-associated drinks. The present study, although it includes a very small number of cases diagnosed with colon diverticulosis-diverticulitis associated with polyposis at the same intestinal level, identifies the presence of increased circulating concentrations of this enzyme in the serum. Its serum levels are tracked “dynamically” throughout a year after the diagnosis and start of the therapy. The study calls into question the release of the enzyme from the edge of the enterocytes’ brush-like edge, leading to the pathogenic disturbance of regional redox homeostasis. The hypothesis gives the circulating values of GGT predictive value for cellular oxidative stress, as well as for indirectly expressing the glutathione level in cytosol.

Osteopontin – a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease

“…Another incompatibility of not being included in the study group was the association with chronic inflammatory diseases such as lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, infectious endocarditis, psoriasis, because it could have influenced the results of serum determinations due to the inflammatory action of autoimmune type 28 .…”

Diagnostic utility of selected faecal biochemical parameters in the determination of acute diarrhoea and associated defecation stooling characteristics in dogs: An observational study

“…Gamma-glutamyl transferase is predominantly found in the cell membranes and in small portions in the cytoplasm of enterocytes. The levels of GGT increase when they lose their anchorage within the membranes of these cells ( Bălăeţ et al, 2018 ). These descriptions of the intestinal metabolism of the faecal biochemical parameters in this study suggest that compromised gut health, as may manifest in diarrhoea, can affect the levels of these parameters.…”

Determining the electric potential of blood – a possible screening method at the population level

“…One example of events that could lead to such outcomes is inflammation, where disproteinemia, hyperfibrinogenmia and circulating inflammatory markers are circulating (C. BĂLĂEȚ & al. [2]).…”

“…Moreover, neoplasm like modifications, which feature changes in proteins (C. BĂLĂEȚ & al. [2]), lead to the apparition of novel electrical charges which interfere with the normal blood components.…”

“…Regardless of the physical location of the malfunction, diseases are the clinical expression of various cellular metabolic dysregulations, which also lead to changes in the blood physio-chemical and electrical properties (C. BĂLĂEȚ & al. [1,2], G. MANOLE [3]).…”