Gamma-Glutary Transferase: A Novel Biomarker for Predicting Coronary Artery Disease

Bijapur, Sandeep; BS, Arun; Nanjappa, Manjunath C; P, Tejeswar Reddy; Katheria, Rockey

doi:10.21088/jcms.2454.7123.6120.5

JCMS

2020

DOI: 10.21088/jcms.2454.7123.6120.5

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Gamma-Glutary Transferase: A Novel Biomarker for Predicting Coronary Artery Disease

Sandeep Bijapur¹,

Arun BS²,

Manjunath C Nanjappa³

et al.

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Serum Gamma Glutamyltransferase (GGT) in Coronary Artery Disease

Singh¹,

Kapoor²,

Khanna³

et al. 2022

Annals of Cardiac Anaesthesia

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Background: There is a need to identify novel markers for CAD, independent of traditional CV risk factors. One of these is gamma-glutamyl transferase (GGT), a marker of increased oxidative stress. Given the high prevalence of CAD in Asian Indians, the link of GGT and CAD in them needs to be studied. Aim: To assess GGT in patients with angiographically documented CAD. Methods and Results: Two hundred patients aged 58.1 ± 9.95 years, 73% males, hypertension 56%, diabetes 40% were included. Mean GGT was 63.6 ± 44.33 (10–269 U/L). The levels of GGT progressively increased in those with single/double or triple-vessel CAD (36.5, 61.5, and 87 U/L, respectively, P < 0.001). Using objective criteria of CAD burden (SYNTAX and Gensini scores), we reaffirmed these findings. GGT in patients with SYNTAX tertiles 0–22, 23–32, and ≥ 33 was 33, 62, and 97 U/L, respectively and in Gensini tertiles 0–17.65, 17.66–56.65, ≥56.66 was 32, 52, and 88 U/L, respectively, all P < 0.001. SYNTAX score ≥ 23 was present in only 23% patients in GGT tertile 1 (<41 U/L), whereas60% and 94% in GGT tertiles 2 and 3 had SYNTAX ≥ 23. Significant positive correlation was seen between GGT and SYNTAX (r = 0.634) and Gensini score (r = 0.772). Conclusions: In this study, GGT had an independent correlation with angiographic severity of CAD and SYNTAX and Gensini scores. Although the existing evidence seems biologically plausible, more studies are needed to explore the potential role of this inexpensive marker for predicting disease burden in patients with CAD.

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Serum Gamma Glutamyltransferase (GGT) in Coronary Artery Disease

Singh¹,

Kapoor²,

Khanna³

et al. 2022

Annals of Cardiac Anaesthesia

View full text Add to dashboard Cite

show abstract

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Gamma-Glutary Transferase: A Novel Biomarker for Predicting Coronary Artery Disease

Cited by 1 publication

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Serum Gamma Glutamyltransferase (GGT) in Coronary Artery Disease

Serum Gamma Glutamyltransferase (GGT) in Coronary Artery Disease

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