Gamma Interferon Does Not Enhance Clearance of<i>Pseudomonas aeruginosa</i>but Does Amplify a Proinflammatory Response in a Murine Model of Postseptic Immunosuppression

Murphey, E. D.; Herndon, David N.; Sherwood, Edward R.

doi:10.1128/iai.72.12.6892-6901.2004

Cited by 33 publications

(30 citation statements)

References 60 publications

(48 reference statements)

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“…The deleterious role of IFN-γ was demonstrated by its capacity to increase death when injected in mice, particularly when acting in synergy with TNF-α (12). This deleterious effect was also shown in the CLP model of polymicrobial peritonitis (92) and in a CLP model followed by a P. aeruginosa infection (93). Polymicrobial peritonitis performed in IFN-γ receptor-deficient mice (94) or in rats given anti-IFN-γ antibodies (95) led to the similar demonstration of this negative role.…”

Section: Nk Cells As a Source Of Inflammatory Cytokines And Antimicromentioning

confidence: 64%

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

Souza-Fonseca-Guimarães

Adib‐Conquy

Cavaillon

2011

Mol Med

136

125

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Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their discovery, NK cells were also demonstrated to contribute to the fight against bacterial infection, particularly because of crosstalk with other leukocytes. A wide variety of immune cells are now recognized to interact with NK cells through the production of cytokines such as interleukin (IL)-2, IL-12, IL-15 and IL-18, which boost NK cell activities. The recent demonstration that NK cells express pattern recognition receptors, namely Toll-like and nucleotide oligomerization domain (NOD)-like receptors, led to the understanding that these cells are not only under the control of accessory cells, but can be directly involved in the antibacterial response thanks to their capacity to recognize pathogen-associated molecular patterns. Interferon (IFN)-γ is the predominant cytokine produced by activated NK cells. IFN-γ is a key contributor to antibacterial immune defense. However, in synergy with other inflammatory cytokines, IFN-γ can also lead to deleterious effects similar to those observed during sepsis. Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances.

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Section: Nk Cells As a Source Of Inflammatory Cytokines And Antimicromentioning

confidence: 64%

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

Souza-Fonseca-Guimarães

Adib‐Conquy

Cavaillon

2011

Mol Med

136

125

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“…Subjects with genetic deficiencies in IFN-c protein or receptor have increased susceptibility to mycobacterial infection [46,61]. Several families are reported to be vulnerable to disseminated MAC disease, and their immunocompromise is caused by the decrease in IFN-c production [62,63] or by IFN-c receptor abnormality [64].…”

Section: Mycobacterium Avium Complex Infectionmentioning

confidence: 99%

Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms

Fuschillo¹,

Felice²,

Balzano³

2008

Eur Respir J

184

124

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Bronchiectasis is a chronic and debilitating lung disease, characterised by irreversible dilatation of the bronchi as consequence of airway injury and remodelling due to recurrent or chronic airway inflammation and infection. The underlying aetiologies include autoimmune diseases, severe infections, genetic abnormalities and acquired disorders.The pathogenesis of bronchiectasis is poorly understood. Three distinct pathogenetic elements, namely infection, inflammation and enzymatic actions, which interact with each other, have been implicated in the pathophysiology of bronchiectasis.Some recent observations indicate that airway inflammation in bronchiectasis comes from a deregulated cytokine network independent of bacterial airway colonisation.In the present review, current knowledge about cellular and molecular inflammatory events in the dynamic process of host-pathogen interaction that are thought to play a relevant role in the pathogenic mechanisms of airway wall destruction leading to bronchiectasis are discussed.

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“…Imbalances in this ratio may result in moderate to severe inhibition or functional alteration to critical immune system activities. It was previously demonstrated that trauma and sepsis favor a Th2-dominant status (17,18). As invasive surgeries often result in significant tissue trauma, the same conclusion may be drawn for surgical patients.…”

Section: Discussionmentioning

confidence: 71%