Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice

Cao, Wenming; Shen, Lin; Xia, Qi; Du, Yong-lan; Yang, Qian; Zhang, Mengying; Lu, Yiqing; Xu, Jing; Duan, Shumin; Xia, Jun; Feng, Guoping; Xu, Jia; Luo, Jiancheng

doi:10.1016/j.neuron.2018.03.006

Cited by 23 publications

(32 citation statements)

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“…6 Knock-in (KI) mice overexpressing neuroligin 3 (an ASC-associated mutation) exhibit reduced coupling between low gamma amplitude and the theta phase, but a stronger and wider coupling between high gamma and theta rhythms during social interaction, indicating a dysfunction of temporal information integration in the local circuits. 15 The KI mice also recruit fewer mPFC neurons to lock gamma and theta oscillations during social interactions and have a lower probability of locking in the social state, while exhibiting a higher probability of locking during the quiet state. 15 Using optogenetic techniques, INs stimulated at 40 Hz nested at 8 Hz, show enhanced power and coupling strength of gamma and theta bands.…”

Section: Subpallium Mgementioning

confidence: 96%

“…15 The KI mice also recruit fewer mPFC neurons to lock gamma and theta oscillations during social interactions and have a lower probability of locking in the social state, while exhibiting a higher probability of locking during the quiet state. 15 Using optogenetic techniques, INs stimulated at 40 Hz nested at 8 Hz, show enhanced power and coupling strength of gamma and theta bands. 15 This stimulation enhances social preference within both wild-type (WT) and KI mice, while constant 40 Hz and 8 Hz nested in 20 Hz, has no effect, and a higher frequency of 80 Hz inhibits social preference in both WT and KI mice.…”

Section: Subpallium Mgementioning

confidence: 96%

“…15 Using optogenetic techniques, INs stimulated at 40 Hz nested at 8 Hz, show enhanced power and coupling strength of gamma and theta bands. 15 This stimulation enhances social preference within both wild-type (WT) and KI mice, while constant 40 Hz and 8 Hz nested in 20 Hz, has no effect, and a higher frequency of 80 Hz inhibits social preference in both WT and KI mice. 15 Collectively, these studies support the hypothesis that GABAergic INs in the PFC play a crucial role in the regulation of behavior and information processing that are hindered in ASC.…”

Section: Subpallium Mgementioning

confidence: 99%

“…12,13 Impairment or loss of parvalbumin (PV) INs may contribute to E/I balance disruption and consequently desynchronize neuronal oscillations that coordinate the activity of distant brain regions. [14][15][16][17] Changes in neuronal activity and oscillations in individuals with ASC are associated with, or even predict, sensory and cognitive symptoms of autism. 11,16 Gamma deficits in the first 3 years of life predict difficulties in language development, cognition, and switching attention, which are implicated in ASC.…”

Section: Introductionmentioning

confidence: 99%

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Cortical interneuron function in autism spectrum condition

et al. 2018

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Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC. Finding common physiological mechanisms that underlie neurodevelopmental disorders may lead to novel pharmacological targets and candidates that could improve the cognitive and emotional symptoms associated with ASC.

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Section: Subpallium Mgementioning

confidence: 96%

Section: Subpallium Mgementioning

confidence: 96%

Section: Subpallium Mgementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical interneuron function in autism spectrum condition

et al. 2018

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“…Using ecological paradigm and hyperscanning techniques, we found brain‐to‐brain coupling of gamma rhythms between both mothers and children 118 and romantic partners 198 during moments of behavioral synchrony. Gamma rhythms have been shown in both animal 199,200 and human 201,202 studies to index brain maturity, highlighting the role of synchrony in fine‐tuning this maturity. Gamma rhythms and prediction error in visceromotor cortex and motivation areas amplify feelings but blur the distinction of self and other, due to the agranularity of these regions 203 .…”

Section: Synchrony From Infancy To Adulthood: the Unfolding Of Resilimentioning

confidence: 99%

What is resilience: an affiliative neuroscience approach

2020

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Resilience – a key topic in clinical science and practice – still lacks a clear conceptualization that integrates its evolutionary and human‐specific features, refrains from exclusive focus on fear physiology, incorporates a developmental approach, and, most importantly, is not based on the negation (i.e., absence of symptoms following trauma). Building on the initial condition of mammals, whose brain matures in the context of the mother's body and caregiving behavior, we argue that systems and processes that participate in tuning the brain to the social ecology and adapting to its hardships mark the construct of resilience. These include the oxytocin system, the affiliative brain, and biobehavioral synchrony, all characterized by great flexibility across phylogenesis and ontogenesis. Three core features of resilience are outlined: plasticity, sociality and meaning. Mechanisms of sociality by which coordinated action supports diversity, endurance and adaptation are described across animal evolution. Humans' biobehavioral synchrony matures from maternal attuned behavior in the postpartum to adult‐adult relationships of empathy, perspective‐taking and intimacy, and extends from the mother‐child relationship to other affiliative bonds throughout life, charting a fundamental trajectory in the development of resilience. Findings from three high‐risk cohorts, each tapping a distinct disruption to maternal‐infant bonding (prematurity, maternal depression, and early life stress/trauma), and followed from birth to adolescence/young adulthood, demonstrate how components of the neurobiology of affiliation confer resilience and uniquely shape the social brain.

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Increasing astrogenesis in the developing hippocampus induces autistic‐like behavior in mice via enhancing inhibitory synaptic transmission

Chen

Zhao

et al. 2021

Glia

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Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized primarily by impaired social communication and rigid, repetitive, and stereotyped behaviors. Many studies implicate abnormal synapse development and the resultant abnormalities in synaptic excitatory-inhibitory (E/I) balance may underlie many features of the disease, suggesting aberrant neuronal connections and networks are prone to occur in the developing autistic brain. Astrocytes are crucial for synaptic formation and function, and defects in astrocytic activation and function during a critical developmental period may also contribute to the pathogenesis of ASD. Here, we report that increasing hippocampal astrogenesis during development induces autistic-like behavior in mice and a concurrent decreased E/I ratio in the hippocampus that results from enhanced GABAergic transmission in CA1 pyramidal neurons. Suppressing the aberrantly elevated GABAergic synaptic transmission in hippocampal CA1 area rescues autistic-like behavior and restores the E/I balance. Thus, we provide direct evidence for a developmental role of astrocytes in driving the behavioral phenotypes of ASD, and our results support that targeting the altered GABAergic neurotransmission may represent a promising therapeutic strategy for ASD.

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Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice

Cited by 23 publications

References 0 publications

Cortical interneuron function in autism spectrum condition

Cortical interneuron function in autism spectrum condition

What is resilience: an affiliative neuroscience approach

Increasing astrogenesis in the developing hippocampus induces autistic‐like behavior in mice via enhancing inhibitory synaptic transmission

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