Gamma probe‐directed lymphatic mapping and sentinel lymphadenectomy in primary melanoma: Reliability of the procedure and analysis of failures after long‐term follow‐up

Jacobs, Ira; Chevinsky, Aaron; Swayne, Lawrence C.; Magidson, Jory G.; Britto, Errol J.; Smith, Thomas J.

doi:10.1002/jso.1088

Cited by 56 publications

(24 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found in our consecutive series that SLN biopsy is a sensitive method to identify micrometastases as at least one SLN was identified at operation in 98.2% (274 of 279 cases) compared to reported rates ranging from 88% to 99% (Table V). In the 274 cases, we removed 614 SLNs, a median of 2 per patient, and in 22% there was drainage to more than one lymph node basin, a finding in agreement with other studies [8,11,[16][17][18].…”

Section: Discussionsupporting

confidence: 90%

Staging patients with cutaneous malignant melanoma by same-day lymphoscintigraphy and sentinel lymph node biopsy: A single-institutional experience with emphasis on recurrence

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

Staging patients with cutaneous malignant melanoma by same-day lymphoscintigraphy and sentinel lymph node biopsy: A single-institutional experience with emphasis on recurrence

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Nowadays, a standardized protocol combines preoperative dynamic lymphoscintigraphy and intraoperative blue-dye injection with gamma probe guidance [5]. Nevertheless, a prospective series of 103 melanoma patients showed that an isotopic mapping alone based on dynamic lymphoscintigraphy and gamma probe was a reliable procedure [17]. These results confirmed previous findings suggesting good success rates when using the radiotracer method singly Table 8 n.s.…”

Section: Discussionsupporting

confidence: 82%

Gamma-Probe-Directed Lymphatic Mapping and Sentinel Lymphadenectomy in Primary Cutaneous Melanoma

et al. 2002

View full text Add to dashboard Cite

Background: Radiotracer and blue-dye lymphatic mapping is a recommended combined method to guide sentinel lymphadenectomy and full regional lymph node dissection in selected patients with cutaneous melanoma. Objective: To evaluate the diagnostic accuracy and the prognostic value of gamma-probe-directed lymphatic mapping in cutaneous melanomas. Methods: Sixty-five stage I and II melanoma patients underwent gamma-probe-directed lymphatic mapping. Sentinel lymph nodes were studied by both conventional and immunohistochemical stainings. The median follow-up was 11 months. Results: Sensitivities of preoperative and intraoperative sentinel lymph node detection were 100 and 98%, respectively. Only 1 failure of detection and 1 missed same-basin metastasis were experienced in the axillary and cervical areas, respectively. Eleven patients (16.9%) had sentinel node metastases leading to adjuvant therapy. Conclusion: Gamma-probe-directed lymphatic mapping is useful for staging melanoma. However, in the expectation of a more specific identification of the sentinel lymph node, the standard protocol remains recommended for exploring the axillary and cervical areas. The histological examination supported in some cases by immunohistochemistry remains mandatory in all cases.

show abstract

“…The association of technetium-labeled sulfur colloid and blue dye injection techniques in adults proved to have an overall accuracy rate of 96-100% and over 90% in predicting axillary metastases in cases with breast cancer and in the staging of malignant melanoma respectively [9,10,26,27]. Our data showed that both the procedures can be performed safely in childhood allowing accuracy in the identification of the sentinel node, however our figures cannot support a benefit of the association of the two techniques.…”

Section: Discussionmentioning

confidence: 54%

Sentinel node biopsy in pediatric soft tissue sarcomas of extremities

Corti

Dall’Igna

Bisogno

et al. 2008

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundSentinel Node Biopsy is an established staging technique in many adult malignancies. However, only few reports describe this procedure for the evaluation of regional lymph nodes in childhood and adolescents. Our experience with sentinel node biopsy in soft tissue sarcomas of extremities in children is reported.MethodsSeventeen children were evaluated with sentinel node biopsy between 2002 and 2007: 11 at initial surgery, 5 at primary re‐excision, 1 at local relapse. The diagnosis was rhabdomyosarcoma in 5 and other soft tissue sarcomas in 12: Ewing/PNET sarcoma 6, epithelioid sarcoma 1, malignant peripheral‐nerve‐sheath tumor 1, undifferentiated sarcoma 1, myxoid liposarcoma 2, adult‐type fibrosarcoma 1. Primary sites included lower limbs (8), upper limbs (9). Mapping of nodes was performed with lymphoscintigraphy plus intra‐operative injections with blue‐dye in 14 cases, with lymphoscintigraphy and intra‐operative injections alone in 2 and 1, respectively.ResultsOf the 17 lymphatic regions (9 axilla, 8 inguinal), 16 were identified with lymphoscintigraphy, 15 by intra‐operative injections. Thirty‐five lymph nodes were removed. Nodes were positive for metastasis in two patients with alveolar rhabdomyosarcoma and undifferentiated sarcoma. There were no complications. No further lymph node metastases were recognized either at diagnosis or during the follow‐up (6–78 months).ConclusionsSentinel node biopsy was technically feasible, reliable, and free of complications. It could be an alternative to aggressive or random biopsies for extremity rhabdomyosarcoma and it can contribute to define those non‐rhabdomyosarcoma soft tissue sarcomas that spread to regional nodes. Pediatr Blood Cancer 2009;52:51–54. © 2008 Wiley‐Liss, Inc.

show abstract

Gamma probe‐directed lymphatic mapping and sentinel lymphadenectomy in primary melanoma: Reliability of the procedure and analysis of failures after long‐term follow‐up

Cited by 56 publications

References 18 publications

Staging patients with cutaneous malignant melanoma by same-day lymphoscintigraphy and sentinel lymph node biopsy: A single-institutional experience with emphasis on recurrence

Staging patients with cutaneous malignant melanoma by same-day lymphoscintigraphy and sentinel lymph node biopsy: A single-institutional experience with emphasis on recurrence

Gamma-Probe-Directed Lymphatic Mapping and Sentinel Lymphadenectomy in Primary Cutaneous Melanoma

Sentinel node biopsy in pediatric soft tissue sarcomas of extremities

Contact Info

Product

Resources

About