Gamma Radiation Induced Contraction of Alkyne Modified Polymer Hydrogels

Brevé, Tobias G.; Liu, Huanhuan; Denkova, Antonia G.; Eelkema, Rienk

doi:10.26434/chemrxiv.14627328.v1

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…These secondary g-irradiation induced crosslinks result in an increased hydrogel stiffness and a significantly reduced hydrogel volume. 48 Moreover, the diffusivity of the hydrogel loaded proteins is thus further restrained due to the increased crosslink density, which explains why no protein release was observed. All together, we were not able to perform proper CL triggered release experiments, due to the inference caused by the residual alkyne groups.…”

Section: Scheme 2 Synthetic Pathway For the 5-step Synthesis Of Bis-azide Crosslinker C2mentioning

confidence: 99%

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

Eelkema

Denkova

Brevé

et al. 2021

Preprint

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Stimuli-responsive soft materials enable controlled release of loaded drug molecules and biomolecules. Controlled release of potent chemotherapeutic or immunotherapeutic agent is crucial to reduce unwanted side effects. In an effort to develop controlled release strategies that can be triggered using Cerenkov luminescence, we have developed polymer hydrogels that can release doxorubicin, bovine serum albumin and immunoglobulin G using light (254 nm – 375 nm) as a trigger. We describe the synthesis and photochemical characterisation of two light sensitive phenacyl bis-azide crosslinkers that are used to prepare transparent self-supporting hydrogel patches. One crosslinker was designed to optimize the overlap with the Cerenkov luminescence emission window, bearing an -extended phenacyl core, resulting in a high quantum yield (14%) of photocleavage when irradiated with 375 nm light. We used the extended phenacyl crosslinker for the preparation of protein-loaded dextran hydrogel patches, which showed efficient and selective dosed release of bovine serum albumin or immunoglobulin G after irradiation with 375 nm light. Based on the high quantum yield, efficient release and large overlap with the Cerenkov window, we envision application of these photosensitive soft materials in radiation targeted drug release.

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Section: Scheme 2 Synthetic Pathway For the 5-step Synthesis Of Bis-azide Crosslinker C2mentioning

confidence: 99%

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

Eelkema

Denkova

Brevé

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

Eelkema

Denkova

Brevé

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Stimuli-responsive soft materials enable controlled release of loaded drug molecules and biomolecules. Controlled release of potent chemotherapeutic or immunotherapeutic agent is crucial to reduce unwanted side effects. In an effort to develop controlled release strategies that can be triggered using Cerenkov luminescence, we have developed polymer hydrogels that can release doxorubicin, bovine serum albumin and immunoglobulin G using light (254 nm -375 nm) as a trigger. We describe the synthesis and photochemical characterisation of two light sensitive phenacyl bis-azide crosslinkers that are used to prepare transparent self-supporting hydrogel patches. One crosslinker was designed to optimize the overlap with the Cerenkov luminescence emission window, bearing an p-extended phenacyl core, resulting in a high quantum yield (14%) of photocleavage when irradiated with 375 nm light. We used the extended phenacyl crosslinker for the preparation of protein-loaded dextran hydrogel patches, which showed efficient and selective dosed release of bovine serum albumin or immunoglobulin G after irradiation with 375 nm light. Based on the high quantum yield, efficient release and large overlap with the Cerenkov window, we envision application of these photosensitive soft materials in radiation targeted drug release.

show abstract

Gamma Radiation Induced Contraction of Alkyne Modified Polymer Hydrogels

Abstract: We describe the gamma radiation induced crosslinking of alkyne-modified dextran polymer gels. Crosslinking of the alkyne moieties leads to gel contraction and fusion with other gel objects, and can be used for controlled release.

Cited by 2 publications

References 26 publications

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

Light sensitive phenacyl crosslinked dextran hydrogels for controlled delivery

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