Gamma-Radiation Monitoring of Luminescent Porous Silicon for Tumor Imaging

Галушка, В. В.; Belobrovaya, O. Ya.; Bratashov, Daniil N.; Kondrateva, O. Yu.; Polyanskaya, V. P.; Sidorov, V. I.; Yagudin, I. T.; Терин, Д. В.

doi:10.1007/s12668-018-0544-1

Cited by 3 publications

(1 citation statement)

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“…More than 20 years after the initial discovery of porous silicon (pSi) photoluminescence by Professor Canham, and his subsequent work on the fabrication of bioactive pSi [1], there remains significant ongoing interest in its biomedical applications, including therapeutic delivery, medical imaging, and theranostics [2][3][4][5][6][7][8][9][10][11][12][13]. PSi possesses a highly tuneable porous nanostructured network and can be fabricated into a variety of different forms, ranging from thin films [14], nanowires [15], and micro-and nanoparticles [6,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Controlling and Predicting the Dissolution Kinetics of Thermally Oxidised Mesoporous Silicon Particles: Towards Improved Drug Delivery

2019

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Porous silicon (pSi) continues to receive considerable interest for use in applications ranging from sensors, biological scaffolds, therapeutic delivery systems to theranostics. Critical to all of these applications is pSi degradation and stabilization in biological media. Here we report on progress towards the development of a mechanistic understanding for the dissolution behavior of native (unoxidized) and thermally oxidized (200–600 °C) pSi microparticles. Fourier transform infrared (FTIR) spectroscopy was used to characterize the pSi surface chemistry after thermal oxidation. PSi dissolution was assessed using a USP method II apparatus by monitoring the production of orthosilicic acid, and the influence of gastro-intestinal (GI) fluids were examined. Fitting pSi dissolution kinetics with a sum of the exponential model demonstrated that the dissolution process strongly correlates with the three surface hydride species and their relative reactivity, and was supported by the observed FTIR spectral changes of pSi during dissolution. Finally, the presence of GI proteins was shown to hamper pSi dissolution by adsorption to the pSi surface acting as a barrier preventing water attack. These findings are significant in the optimal design of pSi particles for oral delivery and other controlled drug delivery applications.

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