Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors

Abstract

A general model for predicting the thermophysical properties of refrigerant/lubricant mixtures has been developed based on applicable theory for the excess Gibbs energy of nonideal solutions. In our approach, flexible thermodynamic forms are chosen to describe the properties of both the gas and liquid phases of refrigerant/lubricant mixtures. After an extensive study of models for describing nonideal liquid effects, the Wohl [3]‐suffix equations, which have been extensively used in the analysis of hydrocarbon mixtures, have been developed into a general form applicable to mixtures where one component is a polyolester or alkylbenzene lubricant. We have developed a nonideal solution computer code, based on the Wohl model that predicts dew point or bubble point conditions over a wide range of composition and temperature and includes the calculation of the enthalpy and entropy of refrigerant/lubricant mixtures. Our present analysis includes the thermodynamic properties of an ideal solution mixture and the corrections due to nonideal solution behavior. These nonideal solution corrections are based on analysis of the excess Gibbs energy of the mixture. We find that these nonideal solution corrections are small (<4%) for most refrigerant/lubricant mixtures, except at very low temperatures. © 2009 American Institute of Chemical Engineers AIChE J, 2009

Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivry gland epithelial cells

“…Ionizing radiation and direct contact with asbestos are environmental risk factors for the development of salivary gland neoplasms. 3 In addition, Milena et al 4 reported that the presence of CMV antigens in different histological types of Salivary gland carcinoma (SGC) may play an important role in carcinogenesis by increasing IL-6 production, inhibiting apoptosis and inducing tumor development. Bianca et al 1 also suggested that the expression of apoptosis-regulating miRNAs in salivary gland tumors is associated with salivary gland tumorigenesis.…”

Salivary gland neoplasms in non‐human primates: A case series and brief literature review

“…The etiology of salivary gland tumors is uncertain in humans; however, several studies have indicated radiation exposure as a risk factor . DNA damage from radiation causes chromosomal breaks and aberrations, which may predispose to tumor development . In NHPs, there is little research regarding radiation exposure and salivary gland tumors.…”

Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma

“…Previous findings from our group showed that apoptosis capacity and DNA repair capacity in response to gamma irradiation were significantly reduced in patients with SGC. 13, 26 Experimental data revealed that BRCA1 modulates cellular susceptibility to apoptosis induced by gamma radiation, 27 and BRCA1 mutations slow the rate of repair of radiation-induced double-strand breaks. 28 BRCA1 is expressed in both acinar and ductal epithelial cells in the salivary gland, and its expression is correlated with proliferation.…”

“…In support of this concept, we previously found reduced DNA repair capacity in SGC patients compared to cancer-free controls. 13 …”