Gamma radiation synthesis optimization of a novel polymer and its possible applications in antimicrobial and antitumor fields

Mostafa, Tahia B.; Awadallah‐F, Ahmed; Shehata, Mona M. K.

doi:10.1007/s00044-012-9993-1

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Maleic anhydride (MAH) is a polar compound containing many functional groups, especially the unsaturated double bonds, which is easy to polymerize with other polymers by adding some agents or by irradiation. , Moreover, the anhydride groups can also react with hydroxyl, carboxyl, amine, and other functional groups. Therefore, MAH functionalization of some nonpolar polymers is beneficial to increase their compatibility with polar polymers and improve the adhesion of materials and the interaction between fillers and polymers. − Dang and co-workers reported PVDF/PP composites with high dielectric properties.…”

Section: Introductionmentioning

confidence: 99%

Physical and Rheological Properties of Maleic Anhydride-Incorporated PVDF: Does MAH Act as a Physical Crosslinking Point for PVDF Molecular Chains?

et al. 2019

ACS Omega

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The miscibility and physical and rheological properties of binary poly(vinylidene fluoride)/maleic anhydride (PVDF/MAH) blends have been systematically investigated. MAH was found to be miscible with PVDF by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Fourier transform infrared (FTIR) investigations provided positive evidence for the specific interaction between the carbonyl groups of MAH and the methylene groups of PVDF. Rheological measurements showed that both the storage modulus and the melt viscosity of PVDF increase with the addition of MAH, followed by a decrease with excess MAH. In addition, the elongation of the PVDF/MAH blend with 10 wt % MAH is 589.7%, which is almost 5 times that of neat PVDF. It is concluded that MAH small molecules act as physical “crosslinking” points for the neighboring PVDF molecule chains due to this specific interaction between PVDF and MAH. Such a physical crosslinking function enhances the storage modulus, viscosity, and mechanical properties of PVDF.

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Section: Introductionmentioning

confidence: 99%

Physical and Rheological Properties of Maleic Anhydride-Incorporated PVDF: Does MAH Act as a Physical Crosslinking Point for PVDF Molecular Chains?

et al. 2019

ACS Omega

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“…In recent years, many studies on the synthesis and hydrolysis properties of polymer-drug conjugates of NSAIDs such as: Naproxen (Bonina et al, 2001), ibuprofen (Babazadeh, 2006, Chang et al, 1998, Davaran and Entezami, 1998, Kim et al, 2005, ketoprofen (Bonina et al, 2001, Kenawy et al, 2008, Indomethacin (Duarte et al, 2006, Bonina et al, 1995, Kim et al, 1998 and fenoprofen (Duarte et al, 2006, Zovko et al, 2001) have been presented. Polymeric antitumor and antimicrobial agents represent an important and new direction that is developing in the field of both pharmacology and biomaterials as well (Kenawy et al, 2014, Mostafa et al, 2013. The antimicrobial property of a polymer plays an important role for many of its applications (Santos et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of polymeric prodrug conjugate systems based on poly (p-hydroxystyrene): In vitro hydrolysis behavior and antibacterial activity

Kenawy¹,

El‐Shehawy²,

El-Sigeny³

et al. 2016

Int. J. Adv. Res. Biol. Sci

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The synthesis and in-vitro evaluation of a novel polymeric systems based on linear poly(p-hydroxystyrene) for targeted controlled release have been described. Linear poly(p-hydroxystyrene) (PHS) functionalized with chloroacetyl groups was first prepared by reacting PHS with chloroacetyl chloride, in presence of pyridine as a catalyst, with degree of chloroacetylation ranged from 87 to 96 mol%. The resulting chloroacetylated-PHS (CPHS) was then coupled with each of sodium diclofenac and 1,3-diaminopropane affording the corresponding polymers P1 and P3, respectively, in quantitative loading yields. Their structures were confirmed by means of FTIR, 1 H-NMR as well as by elemental analysis. The hydrolysis in the heterogeneous system of CPHS-diclofenac conjugate was performed in buffer solutions (pH 1.2 ,7.4 and 9) at 37 o C by UV spectroscopy at the absorption wavelength of diclofenac sodium (λ max = 276 nm). The drug could be released by selective hydrolysis of the ester bond at the side of the drug moiety. The hydrolytic behavior was found to be mainly dependant on the pH value of the hydrolysis medium. The obtained results suggested that this polymer could be useful in controlled release systems after in-vivo examinations. The antibacterial activities of the modified polymers were also tested against Staphylococcus aureus, Enterococcus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumoniae. They showed good antibacterial activity which differed according to the concentration of the polymer as obtained from minimum inhibitory concentration (MIC) studies

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Organic bioelectronic plasma polymerised polyterpenol thin films: preservation of properties relevant to biomedical and organic electronic applications following exposure to sterilising doses of gamma radiation

Grant

Bazaka

Davies

et al. 2017

J Mater Sci: Mater Electron

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Gamma radiation synthesis optimization of a novel polymer and its possible applications in antimicrobial and antitumor fields

Cited by 3 publications

References 41 publications

Physical and Rheological Properties of Maleic Anhydride-Incorporated PVDF: Does MAH Act as a Physical Crosslinking Point for PVDF Molecular Chains?

Physical and Rheological Properties of Maleic Anhydride-Incorporated PVDF: Does MAH Act as a Physical Crosslinking Point for PVDF Molecular Chains?

Synthesis and characterization of polymeric prodrug conjugate systems based on poly (p-hydroxystyrene): In vitro hydrolysis behavior and antibacterial activity

Organic bioelectronic plasma polymerised polyterpenol thin films: preservation of properties relevant to biomedical and organic electronic applications following exposure to sterilising doses of gamma radiation

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