Gamma-Ray-Resistant and -Sensitive Strains of Slime Mold (Dictyostelium discoideum)

Deering, R. A.; Smith, M. S.; Thompson, B. K.; Adolf, Andrej

doi:10.2307/3573240

Cited by 65 publications

(18 citation statements)

References 20 publications

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“…These strains have no shoulder on either the u.v or gamma-ray survival curves ( Fig. 3; see also Deering et al, 1970). Mutants of type 2 [ys5 (radGS), ys14 (radDZ4), ys18 (radHI8) and ys21 (radF2I)I have U.V.…”

Section: Resultsmentioning

confidence: 91%

Genetics of Radiation Sensitivity in the Slime Mould Dictyostelium discoideum

Welker¹,

Deering²

1978

Journal of General Microbiology

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Section: Resultsmentioning

confidence: 91%

Genetics of Radiation Sensitivity in the Slime Mould Dictyostelium discoideum

Welker¹,

Deering²

1978

Journal of General Microbiology

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“…Stable mutants of strain NC-4 have been isolated, which possess varying degrees of greater radiosensitivity . Deering, Smith, Thompson and Adolf (1970) have made a comparison of some of the radiation responses of strain NC-4 with those of two of the mutant strains, ys-18 (D 10 =75 krads) and . Results of these studies suggest that the extreme radiosensitivity of ys-13 relative to NC-4 is due to an impairment of the ability to repair damage induced by gamma-radiation and that ys-18 is intermediate in this regard .…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced Division Delay inDictyostelium Discoideum:Relation to Survival in Resistant and Sensitive Strains

Cleveland

Deering

1972

International Journal of Radiation Biology and Related Studies

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Vegetative amoeboid cells of the cellular slime mould, Dictyostelium discoideum NC-4, are very resistant to gamma-radiation . Mutant strains have been isolated which are significantly more radiosensitive . Studies were conducted to measure division delays and other growth responses after irradiation of strain NC-4 and two mutant strains . Some division of non-surviving (non-colonyforming) cells was observed in all strains . Total cell populations (surviving plus non-surviving cells) in all three strains showed essentially equivalent division-delay responses . However, surviving cells of the mutant strains revealed division delays that were much longer than those of the total cell populations . A model is proposed to interpret these results . A basic premise of the model is that, if more time is allowed for repair of potentially lethal damage incurred by the sensitive strains, cellular survival will be greater . Support for this model was obtained by producing artificially long delays in populations consisting of irradiated mutant cells . Increases in survival were observed for the sensitive strains but not for strain NC-4 .

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“…Initial studies of DNA repair in Dictyostelium focussed on the identification of mutant strains that are sensitive to agents that cause DNA damage. [42][43][44] More recently, the molecular basis of DNA repair in Dictyostelium has started to be addressed. For example, several components of the base excision repair (BER) and nucleotide excision repair (NER) machinery have been shown to be conserved in this organism.…”

Section: Conservation Of Non-homologous End-joining In Dictyosteliummentioning

confidence: 99%

DNA Damage Signalling and Repair in Dictyostelium discoideum

Hsu

Gaudet²,

Hudson³

et al. 2006

Cell Cycle

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Repair of DNA double strand breaks (DSBs) is critical for the maintenance of genome integrity. DNA DSBs can be repaired by either homologous recombination (HR) or nonhomologous end-joining (NHEJ). Whilst HR requires sequences homologous to the damaged DNA template in order to facilitate repair, NHEJ occurs through recognition of DNA DSBs by a variety of proteins that process and rejoin DNA termini by direct ligation. Here we review two recent reports that NHEJ is conserved in the social amoeba Dictyostelium discoideum. Certain components of the mammalian NHEJ pathway that are absent in genetically tractable organisms such as yeast are present in Dictyostelium and we discuss potential directions for future research, in addition to considering this organism as a genetic model system for the study of NHEJ in vivo.

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Gamma-Ray-Resistant and -Sensitive Strains of Slime Mold (Dictyostelium discoideum)

Cited by 65 publications

References 20 publications

Genetics of Radiation Sensitivity in the Slime Mould Dictyostelium discoideum

Genetics of Radiation Sensitivity in the Slime Mould Dictyostelium discoideum

Radiation-induced Division Delay inDictyostelium Discoideum:Relation to Survival in Resistant and Sensitive Strains

DNA Damage Signalling and Repair in Dictyostelium discoideum

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