Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract

Honkanen, Outi; Marvola, Janne; Kanerva, Hanna; Lindevall, Kai; Lipponen, Maija; Kekki, Tommi; Ahonen, Aapo; Marvola, Martti

doi:10.1016/j.ejps.2004.01.008

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…Our findings about disintegration time of magnetic capsules contrasts sharply with those obtained by recent reports (3,4,38). The discrepancy might be due to the pharmaceutical strategies to achieve drug release in the colon (pH-sensitive or enzyme-controlled release), coating thickness and excipients used.…”

Section: Discussioncontrasting

confidence: 86%

“…The majority of enteric and colon delivery systems are based on coated tablets or conventional hard gelatin capsules (3). Nevertheless, capsules made from hydroxypropyl methylcellulose (HPMC) have been successfully manufactured as an alternative to gelatin (4). HPMC capsules have several technical advantages over gelatin capsules including a more irregular surface that provides a strongly adhesion and an excellent compatibility with the polymer (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Enteric Coated Magnetic HPMC Capsules Evaluated in Human Gastrointestinal Tract by AC Biosusceptometry

et al. 2006

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Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Enteric Coated Magnetic HPMC Capsules Evaluated in Human Gastrointestinal Tract by AC Biosusceptometry

et al. 2006

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“…This agrees with the conclusion of Cole et al (2004), who claimed that gelatin capsules and HPMC capsules made from gellan could move down to the stomach rapidly within 20 s. Honkanen et al (2004) reported that HPMC capsules made from carrageenan may adhere to the esophagus leading to a delay in capsule transit.…”

Section: Gamma-scintigraphic Studiessupporting

confidence: 87%

Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration

Guo

et al. 2012

Chin. J. Ocean. Limnol.

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Gelatin has been used in hard capsule shells for more than a century, and some shortcomings have appeared, such as high moisture content and risk of transmitting diseases of animal origin to people. Based on available studies regarding gelatin and vegetable shells, we developed a new type of algal polysaccharide capsule (APPC) shells. To test whether our products can replace commercial gelatin shells, we measured in-vivo plasma concentration of 12 selected volunteers with a model drug, ibuprofen, using high performance liquid chromatography (HPLC), by calculating the relative bioavailability of APPC and Qualicaps® referenced to gelatin capsules and assessing bioequivalence of the three types of shells, and calculated pharmacokinetic parameters with the software DAS 2.0 (China). The results show that APPC shells possess bioequivalence with Qualicaps® and gelatin shells. Moreover, the disintegration behavior of four types of shells (APPC, Vegcaps®, Qualicaps® and gelatin shells) with the content of lactose and radioactive element ( 99m Tc) was observed via gamma-scintigraphic images. The bioavailability and gamma-scintigraphic studies showed that APPC was not statistically different from other vegetable and gelatin capsule shells with respect to in-vivo behavior. Hence, it can be concluded that APPCs are exchangeable with other vegetable and gelatin shells.

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“…The extremely long transit time for the HPMC capsule is due to a high incidence (4 out of 12 subjects) of capsules lodging in the esophagus, leading to transit times of 22, 23, 101, and 143 min compared to the range of 7-24 s for those that did not stick (26). The long transit time of microcrystalline chitosan was the result of a single patient study where the chitosan adhered to the esophageal mucosa for 1.75 h (27).…”

Section: Techniques Used To Evaluate Adhesion Of Solid Dosage Formsmentioning

confidence: 97%

“…However, gamma scintigraphy has been the technique of choice when examining bioadhesion within the esophagus. Studies performed (25)(26)(27) have used gamma scintigraphy to observe the transit of dosage forms within the esophagus of human volunteers. McCargar et al compared an ex vivo porcine model to human gamma scintigraphy work and discovered that the porcine adhesion model was not predictive of esophageal transit in vivo (21).…”

Section: In Vivo Liquid Retention Within the Esophagusmentioning

confidence: 99%

Bioadhesive Dosage Forms for Esophageal Drug Delivery

Batchelor

2005

Pharm Res

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The esophagus as a site for drug delivery has been much overlooked in comparison to the remainder of the gastrointestinal tract. The low permeability and transient nature of the esophagus means that it is unsuitable for delivery of drugs for systemic action. However, esophageal disorders including fungal infection, cancers, motility dysfunction, and damage due to gastric reflux may be treated using locally acting agents that offer benefits of reduced dosage and decreased side effects. Bioadhesive dosage forms that adhere to the esophageal mucosa and prolong contact have been investigated to improve the efficacy of locally acting agents. The rationale for local esophageal drug delivery and its limitations, the factors that determine adhesion to this organ, and the experimental models used in esophageal drug delivery research are reviewed.

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Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract

Cited by 18 publications

References 16 publications

Enteric Coated Magnetic HPMC Capsules Evaluated in Human Gastrointestinal Tract by AC Biosusceptometry

Enteric Coated Magnetic HPMC Capsules Evaluated in Human Gastrointestinal Tract by AC Biosusceptometry

Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration

Bioadhesive Dosage Forms for Esophageal Drug Delivery

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