Gamma transcranial alternating current stimulation for treatment of negative symptoms in schizophrenia: Report of two cases

Haller, Nikolas; Hasan, Alkomiet; Padberg, Frank; Valiengo, Leandro; Palm, Ulrich

doi:10.1016/j.ajp.2020.102423

Cited by 5 publications

(14 citation statements)

References 12 publications

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“…However, 4 studies also included participants diagnosed with schizoaffective disorder [ 43 , 45 , 46 , 53 , 54 ]. Most studies included a specific subgroup of schizophrenia targeting specific symptom domains, such as those having treatment-resistant negative symptoms [ 42 , 50 ], treat-ment-resistant delusions [ 48 ], treatment-resistant auditory hallucinations [ 45 , 46 , 52 , 54 ], or those with cognitive deficits [ 41 , 44 , 47 ]. But few studies seemed to have heterogeneous samples without specific symptom profiles.…”

Section: Resultsmentioning

confidence: 99%

Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review

Pathak

Sreeraj

Venkatasubramanian

2023

Clin Psychopharmacol Neurosci

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Transcranial alternating current stimulation (tACS) may modulate neuronal oscillations by applying sinusoidal alternating current, thereby alleviating associated symptoms in schizophrenia. Considering its possible utility in schizophrenia, we reviewed the literature for tACS protocols administered in schizophrenia and their findings. A scoping review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline in databases and clinical trial registers. The search resulted in 59 publications. After excluding review articles unrelated to tACS, trials without published results or not involving patients with schizophrenia, 14 studies were included. Among the included studies/case reports only 5 were randomized controlled therapeutic trials. The studies investigated the utility of tACS for clinical and neurobiological outcomes. All studies reported good tolerability with only transient mild side effects. It was administered mostly during the working memory task (such as computerized n-back task, dual back task, and computerized digit symbol substitution task) for schizophrenia patients with cognitive deficits and during resting state while targeting positive symptoms. A possible reduction in hallucinations and delusions using alpha tACS, and improvement in negative and cognitive deficits with theta and gamma tACS were reported. Nevertheless, one of the randomized controlled trials targeting hallucinations was negative and rigorous large-sample studies are lacking for other domains. The current evidence for tACS in schizophrenia is preliminary though promising. In future, more sham controlled randomized trials assessing the effect of tACS on various domains are needed to substantiate these early findings.

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Section: Resultsmentioning

confidence: 99%

Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review

Pathak

Sreeraj

Venkatasubramanian

2023

Clin Psychopharmacol Neurosci

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“…Two studies [ 24 , 25 ] used 10 sessions of 40 Hz stimulation over F3/F4 in two and three patients respectively and found improvements in visual attention, word fluency, processing speed, and WM. One case report [ 26 ] also applied 40 Hz stimulation but over P3 area and in a single session, without any influence on cognition.…”

Section: Resultsmentioning

confidence: 99%

“…Risk of bias was evaluated in all listed studies. Twelve studies other than randomized control trials (i.e., case reports, case series and open-label studies) were labeled as “High risk” due to a lack of control group and blinding [ 24 – 27 , 36 – 39 , 43 – 45 , 51 ]. Randomized control trials (RCT) were assessed according to the Cochrane database RoB 2 tool [ 52 ], with the assessed domains being randomization process, deviations from intended interventions, missing outcome data, measurement of the outcome, selection of the reported result and overall bias.…”

Section: Resultsmentioning

confidence: 99%

“… Mean age % female Adverse effects Electrode montage Device No. of sessions Frequency Intensity (peak-to-peak) Duration Scales Cognitive outcomes Other Imaging methods or other biomarkers Follow-up Haller et al [ 25 ] Gamma transcranial alternating current stimulation in patients with negative symptoms in schizophrenia: a case series Visual attention; word fluency; processing speed; WM SCH Case series 3 30.3 ± 6.3 100 Mild site discomfort; phosphenes F3; F4 NeuroConn eldith ® DC-stimulator (Neuroconn, Ilmenau, Germany) 5 days/week for 2 weeks 40 Hz 2 mA 10 min, twice per day RWT; TMT-A/B Improvement in RWT, TMT-A/B – – – Haller et al [ 24 ] Gamma transcranial alternating current stimulation for treatment of negative symptoms in schizophrenia: report of two cases Visual attention; word fluency; processing speed; WM SCH Case series 2 27 50 Phosphenes F3; F4 NeuroConn eldith ® DC-stimulator (Neuroconn, Ilmenau, Germany) 5 days/week for 2 weeks 40 Hz 2 mA 20 min RWT; TMT-A/B Improvement in RWT and TMT-A/B – – – …”

Section: Methodsmentioning

confidence: 99%

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Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

Biačková,

Adamová,

Klírová

2023

Eur Arch Psychiatry Clin Neurosci

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Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that, through its manipulation of endogenous oscillations, can affect cognition in healthy adults. Given the fact that both endogenous oscillations and cognition are impaired in various psychiatric diagnoses, tACS might represent a suitable intervention. We conducted a search of Pubmed and Web of Science databases and reviewed 27 studies where tACS is used in psychiatric diagnoses and cognition change is evaluated. TACS is a safe and well-tolerated intervention method, suitable for multiple-sessions protocols. It can be administered at home, individualized according to the patient'’s anatomical and functional characteristics, or used as a marker of disease progression. The results are varying across diagnoses and applied protocols, with some protocols showing a long-term effect. However, the overall number of studies is small with a great variety of diagnoses and tACS parameters, such as electrode montage or used frequency. Precise mechanisms of tACS interaction with pathophysiological processes are only partially described and need further research. Currently, tACS seems to be a feasible method to alleviate cognitive impairment in psychiatric patients; however, a more robust confirmation of efficacy of potential protocols is needed to introduce it into clinical practise.

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“…Haller et al. [ 20 ] beschreiben außerdem in einem weiteren Fallbericht über zwei Schizophreniepatienten, welche täglich 20 min lang mit γ‑tACS über 2 Wochen stimuliert wurden, eine ähnliche, wenn auch weniger deutliche Verbesserung der Symptome.…”

Section: Tacsunclassified

Transkranielle elektrische Hirnstimulationsverfahren zur Behandlung der Negativsymptomatik bei Schizophrenie

Haller¹,

Hasan

Padberg³

et al. 2021

Nervenarzt

Self Cite

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ZusammenfassungÜber die letzten Jahre entwickelten sich Neuromodulationsverfahren zu einer dritten Säule neben Pharmakotherapie und Psychotherapie in der Behandlung psychischer Erkrankungen. Besonders in der Behandlung von Menschen mit einer Schizophrenie könnten Hirnstimulationsverfahren eine Alternative oder Ergänzung zu den etablierten Therapiestrategien darstellen. Die meist vorhandenen Positivsymptome können zumeist mit Antipsychotika adäquat behandelt werden. Gerade bei Patienten mit Schizophrenie besitzen jedoch Negativsymptome einen überdauernden Krankheitswert und beeinflussen den Verlauf durch globale Antriebsverarmung und beeinträchtigte Kognition im alltäglichen Leben negativ. Dieser Übersichtsartikel stellt eine Zusammenfassung über die verschiedenen nichtinvasiven Hirnstimulationsverfahren transkranielle Gleichstromstimulation (transcranial direct current stimulation, tDCS), Wechselstromstimulation (transcranial alternating current stimulation, tACS) sowie Rauschstromstimulation (transcranial random noise stimulation, tRNS) zur Behandlung der Negativsymptomatik bei Schizophrenie dar. Die neuen transkraniellen Hirnstimulationsverfahren könnten dabei helfen, gestörte neuronale Vernetzungen wieder herzustellen und die Konnektivität vor allem der dorsolateralen präfrontalen Anteile des Kortex zu verbessern. Einige Studien weisen auf eine Verbesserung der Negativsymptome durch Behandlung mit tDCS, tACS bzw. tRNS hin und könnten so neue Therapiemöglichkeiten in der Behandlung der Schizophrenie darstellen.

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Gamma transcranial alternating current stimulation for treatment of negative symptoms in schizophrenia: Report of two cases

Cited by 5 publications

References 12 publications

Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review

Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review

Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

Transkranielle elektrische Hirnstimulationsverfahren zur Behandlung der Negativsymptomatik bei Schizophrenie

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