Gamna Gandy Bodies: The Tobacco Flex appearance

Abstract

Splenic siderotic nodules, also known as Gamna Gandi’s bodies are nodules containing hemosiderin, fibrous tissue and calcium and result of small necrotic haemorrhagic focis in the spleen with a fibroblastic reaction leading to microarchitectural distorsion. Anatomopathological examination show bamboo-shaped small circumscribed nodular siderotic deposits corresponding to fibrous collagenous tissue, impregnated with iron pigments (hemosiderin) and calcium. Herein, we display images of Gamna Gandi’s bodies in a 55-year-old patient with a history of chronic portal thrombosis resulting in portal hypertension. Gamna Gandi’s bodies are easily detected, in most cases on the various cross-sectional imaging techniques as a well-circumscribed millimeteric nodules, with a black central hemorrhage surrounded by a double rim, a pale inner hyperemic rim and a dark outer rim, giving an appearance of “tobacco flecks” (figure 2, D, arrow).