Gangliocytic paraganglioma, a rare cause of upper gastrointestinal bleeding

Smithline, Amy; Hawes, Robert H.; Kopecky, Kenyon K.; Cummings, Oscar W.; Kumar, S. Satish

doi:10.1007/bf01296792

Cited by 20 publications

(15 citation statements)

References 6 publications

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“…Imai et al 3 reported that the incidence of ulceration in these lesions was approximately 40% in the patients previously reported in other countries. Smithline et al 6 reported that ultrasonic endoscopy showed at heterogeneous solid echo continuing from the submucosal layer, and indicated that endoscopic ultrasonography was useful for preoperative differential diagnosis.…”

Section: Discussionmentioning

confidence: 97%

Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection

Nagai¹,

Torishima²,

Nakashima³

et al. 2004

Journal of Gastroenterology

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Gangliocytic paragangliomas are exceedingly rare tumors that arise in close proximity to the papilla of Vater. There are few reports of the endoscopic resection of duodenal gangliocytic paraganglioma. A 61-year-old woman was admitted with a complaint of melena. Endoscopic examination revealed a pedunculated submucosal tumor with erosion in the third portion of the duodenum. Hemostasis, using a gold probe, was performed. Nine days later, we successfully resected the tumor, using endoscopic polypectomy. To determine the depth of tumor invasion, endoscopic ultrasonography was used. The size of the tumor was 3.0 x 2.5 x 1.0 cm. A total of 25 cases of duodenal gangliocytic paraganglioma have been reported in Japan. Generally, this tumor is considered benign. However, resection was performed in many patients because preoperative diagnosis was impossible. In Japan, no previous studies have reported using endoscopic hemostasis, to our knowledge. Our patient is the fourth in Japan to be treated by endoscopic resection. We report on our patient, with a review of the literature.

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Section: Discussionmentioning

confidence: 97%

Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection

Nagai¹,

Torishima²,

Nakashima³

et al. 2004

Journal of Gastroenterology

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“…EUS may be useful in confirming the submucosal location of these tumors. 33 Although these tumors are thought to be benign, metastatic lymphadenopathy, treatment with radiation therapy and jaundice due to bile duct infiltration has been reported. 31,34 Endoscopic resection of GPs is feasible as these tumors are largely benign with a very low rate of metastatic peri-duodenal lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Resection of Nonadenomatous Ampullary Neoplasms

Chahal¹,

Prasad²,

Sanderson

et al. 2007

Journal of Clinical Gastroenterology

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The safety and effectiveness of endoscopic management of ampullary adenomas is well known. However, data on the endoscopic treatment and long-term outcome of nonadenomatous ampullary neoplasms are lacking. We describe our experience with the endoscopic management and the follow-up of 4 patients with nonadenomatous ampullary neoplasms viz, ampullary carcinoid, gangliocytic paraganglioma, ampullary hamartoma in patients with Peutz-Jegher syndrome and Cowdens syndrome.

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“…However, tumors located in the esophagus [10], the third or the fourth portion of the duodenum [11], jejunum, or stomach [7], appendix [12], pancreas [13], or even nasopharynx [14] or lungs have been reported [15][16][17]. In 95% of the cases, the tumor is symptomatic, with 60% of patients presenting with melena [18][19][20] or abdominal pain [21]. Obstruction of the upper digestive tract [6] and obstructive jaundice are uncommon [8,18,22].…”

Section: Discussionmentioning

confidence: 99%

Duodenal gangliocytic paraganglioma with lymph node metastasis and an 8-year follow-up

Barret¹,

Rahmi²,

Huyen³

et al. 2012

European Journal of Gastroenterology & Hepatology

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Gangliocytic paraganglioma (GP) is a rare tumor, usually located in the second part of the duodenum. On pathological examination, GP is characterized by the association of the histological features of paragangliomas, ganglioneuromas, and carcinoid tumors. Classical clinical presentations are upper gastrointestinal bleeding and abdominal pain. Preoperative diagnosis is difficult because of the submucosal site of the tumor, with usually negative mucosal biopsies. Endoscopic ultrasound helps establish the diagnosis and allows lymph node staging, which will guide the choice of the treatment. If GPs usually follow a benign course, metastatic spread to regional lymph nodes treated by surgical resection alone has been reported. We report a case of GP with lymph node metastases treated by duodenopancreatectomy with long-term disease-free survival, suggesting that surgical resection is a reasonable approach for metastatic GPs.

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Gangliocytic paraganglioma, a rare cause of upper gastrointestinal bleeding

Cited by 20 publications

References 6 publications

Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection

Duodenal gangliocytic paraganglioma treated with endoscopic hemostasis and resection

Endoscopic Resection of Nonadenomatous Ampullary Neoplasms

Duodenal gangliocytic paraganglioma with lymph node metastasis and an 8-year follow-up

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