Gangliocytic paraganglioma: An overview and future perspective

Okubo, Yoichiro

doi:10.5306/wjco.v10.i9.300

Cited by 15 publications

(13 citation statements)

References 12 publications

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“…However, diversity of GPs is different from relative consistence of NETs in morphology. More significantly, GPs have a more indolent clinical behavior and favorable prognosis than NETs ( 12 ). Thus, in our opinion, GP is supposed to be differentiated from NET G1.…”

Section: Discussionmentioning

confidence: 99%

Is Gangliocytic Paraganglioma Designated as a Subtype of Composite Paragangliomas and Originated From Pancreas Islet? A Case Report and Review of Literature

Wang

Zhu

2022

Front. Endocrinol.

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Gangliocytic paraganglioma (GP) is quite rare, and origin and entity remain to be elucidated. A 51-year-old man presented with GP as a sessile polyp with a smooth surface that measured about 1 cm in diameter in the descending portion of duodenum. Pathological examination displayed that a neoplasm was predominantly located in the submucosa and infiltrated mucosa focally. The tumor consisted of epithelioid, ganglion-like, and spindle cells admixing in a haphazard way. The epithelioid cells resembled paraganglioma in cytological and architectural features. The ganglion-like cells were scattered and merged with the bland spindle cells in fascicular clusters, which resembled ganglioneuroma. Synaptophysin (Syn), microtubule-associated protein-2 (MAP-2), and chromogranin A (CgA) were positive in the epithelioid and ganglion-like cells in variety, and neurofilament (NF) staining highlighted the ganglion-like cells. S-100 and SOX-10 were positive in the spindle cell proliferation and around the epithelioid cells. Progesterone receptor (PR) was positive in the epithelioid cells. The polyp was resected, and no adjuvant therapy was given. The patient remained with no recurrence in 2 years’ follow-up. Origin of GP is presumed to be related to pancreas islet. GP is distinguished from neuroendocrine tumor (NET) G1 and designated as paraganglioma-ganglioneuroma, a kind of composite paragangliomas.

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Section: Discussionmentioning

confidence: 99%

Is Gangliocytic Paraganglioma Designated as a Subtype of Composite Paragangliomas and Originated From Pancreas Islet? A Case Report and Review of Literature

Wang

Zhu

2022

Front. Endocrinol.

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“… 2 In one case, pancreaticoduodenectomy was performed for suspected malignancy because of an increase in tumor size prior to surgery; however, postoperative histopathological analysis revealed BGH, 5 which can be differentiated from leiomyoma, adenoma, lipoma, leiomyosarcoma, and carcinoid by performing EMR. 3 , 6 , 7 Some studies have suggested that BGH may have malignant potential; however, recurrence of BGH has not been reported. 8 Nevertheless, endoscopic resection may be an option in symptomatic patients or increasing tumor size.…”

Section: Discussionmentioning

confidence: 99%

Giant Brunner's gland hamartoma diagnosed via endoscopic mucosal resection: A case report

et al. 2021

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We report the case of a patient with a giant Brunner's gland hamartoma that was pathologically diagnosed by endoscopic mucosal resection. A 69‐year‐old woman presented with intermittent abdominal pain, and imaging revealed a smooth saccular submucosal tumor, 40 mm in diameter, on the anterior wall of the duodenal bulb. Brunner's gland and smooth muscle tissue were observed on endoscopic ultrasound‐guided fine‐needle aspiration biopsy, which resulted in the preoperative diagnosis of a duplication cyst. However, subsequent endoscopic mucosal resection established a final histopathological diagnosis of Brunner's gland hamartoma.

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“…GP is generally classi ed among NETs [7]. However, diversity of GP is different from relative consistence of NET in morphology, and GP has a more indolent clinical behavior and improved prognosis than NET [8]. Thus, GP is supposed to be differentiated from NET Grade 1.…”

Section: Discussionmentioning

confidence: 99%

Duodenal gangliocytic paraganglioma: a rare case report

Wang²,

Zhu³

2020

Preprint

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Abstract Background Gangliocytic paraganglioma (GP) is quite rare, and origin and entity remain to be elucidated. Case presentation A 51-year-old male presented with a sessile polyp with smooth surface measured about 1cm in diameter in the descending portion of duodenum. Pathological examination displayed a neoplasm located in submucosa, infiltrating into lamina propria. The tumor consisted of epithelioid, ganglion-like and spindle cells admixing in a haphazard way. The epithelioid cells resembled paraganglioma in cytological and architectural features, the ganglion-like cells was scattered, and the spindle cells resembled neurofibroma. Syn, MAP-2 and CgA were positive in the epithelioid and ganglion-like cells in variety and NF highlighted the ganglion-like cells. S-100 and SOX-10 were positive in the sustentacular cells around the epithelioid cells and spindle cell proliferation. PR was also positive. Conclusions Origin of GP is presumed to be related with pancreas islet. GP is supposed to be distinguished with NET G1 and designated as paraganglioma-ganglioneuroma, a kind of composite paraganglioma.

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Gangliocytic paraganglioma: An overview and future perspective

Cited by 15 publications

References 12 publications

Is Gangliocytic Paraganglioma Designated as a Subtype of Composite Paragangliomas and Originated From Pancreas Islet? A Case Report and Review of Literature

Is Gangliocytic Paraganglioma Designated as a Subtype of Composite Paragangliomas and Originated From Pancreas Islet? A Case Report and Review of Literature

Giant Brunner's gland hamartoma diagnosed via endoscopic mucosal resection: A case report

Duodenal gangliocytic paraganglioma: a rare case report

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