Gangliogliomas: A report of five cases

Nair, V.; Suri, V. S.; Tatke, Medha; Rk, Saran; Malhotra, Veena; Singh, Daljit

doi:10.4103/0019-509x.12344

Cited by 29 publications

(1 citation statement)

References 15 publications

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“…Although the condition’s aetiology and pathogenesis remain elusive, it has been hypothesised that AGG originates from glioneuronal precursor cells [ 54 , 55 ]. Anaplastic features typically appear de novo, predominantly in paediatric cases [ 56 ]. Albeit a rare occurrence, it is possible for the anaplastic transformation to originate from benign ganglioglioma, particularly in older patients [ 57 ].…”

Section: Long-term Epilepsy-associated Tumours (Leat) Fcd Associated ...mentioning

confidence: 99%

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Metodiev

Minkin

Ruseva³

et al. 2023

Diagnostics

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Focal cortical dysplasia (FCD) represents a heterogeneous group of morphological changes in the brain tissue that can predispose the development of pharmacoresistant epilepsy (recurring, unprovoked seizures which cannot be managed with medications). This group of neurological disorders affects not only the cerebral cortex but also the subjacent white matter. This work reviews the literature describing the morphological substrate of pharmacoresistant epilepsy. All illustrations presented in this study are obtained from brain biopsies from refractory epilepsy patients investigated by the authors. Regarding classification, there are three main FCD types, all of which involve cortical dyslamination. The 2022 revision of the International League Against Epilepsy (ILAE) FCD classification includes new histologically defined pathological entities: mild malformation of cortical development (mMCD), mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE), and “no FCD on histopathology”. Although the pathomorphological characteristics of the various forms of focal cortical dysplasias are well known, their aetiologic and pathogenetic features remain elusive. The identification of genetic variants in FCD opens an avenue for novel treatment strategies, which are of particular utility in cases where total resection of the epileptogenic area is impossible.

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Section: Long-term Epilepsy-associated Tumours (Leat) Fcd Associated ...mentioning

confidence: 99%

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Metodiev

Minkin

Ruseva³

et al. 2023

Diagnostics

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Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation

et al. 2009

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Intraventricular ganglioglioma: a short illustrated review

Samdani¹,

Torre-Healy

Khalessi

et al. 2009

Acta Neurochir

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The following review of the literature describes the ganglioglioma, an uncommon mixed glioneuronal neoplasm, most often of low-grade histology, with a small, albeit well-documented, malignant potential. These tumors exhibit a strong epileptogenic propensity and most often present as new onset seizures or are discovered after a long history of refractory epilepsy. Despite their indolent course, the importance of gross total resection is well recognized to prevent anaplastic and malignant degeneration. Morphologically, the neoplasm is often cystic with an enhancing mural nodule, but can also be entirely solid. They are most often found in the temporal lobe but have been found throughout the neuraxis. An exceedingly rare location of the ganglioglioma is within the lateral ventricle. A systematic literature search revealed only eight reports documenting the occurrence of a ganglioglioma within the lateral ventricle. We describe an illustrative case of an intraventricular ganglioglioma with a prominent cystic component and enhancing mural nodule, which represents the classic radiographic appearance of gangliogliomas described in other locations. A superior parietal lobule approach offered excellent surgical access for tumor removal and the patient has remained free of neurological deficits following surgery. Regardless of location within the central nervous system, ganglioglioma should be on the differential diagnosis for any cystic mass with a mural nodule, particularly in the setting of epilepsy.

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Gangliogliomas: A report of five cases

Cited by 29 publications

References 15 publications

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Suprasellar ganglioglioma presenting with diabetes insipidus in a young boy: a rare clinical presentation

Intraventricular ganglioglioma: a short illustrated review

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