Ganglion are benign cystic swelling of unknown aetiology that most commonly encountered in the wrist especially dorsal aspect. Women are more frequently affected especially between age of 20-50 years. Although these are asymptomatic but may present with symptoms include wrist pain especially with movement or when a mass is felt, a reduction in range of motion, and a decrease of grip strength. Clinical presentation is usually sufficient for its diagnosis. A case of 25-year-old female suffering from wrist ganglion for few months, has been presented here. After a thorough clinical evaluation, Ruta Graveolens 200 was prescribed followed by placebo for period of four months. This case report demonstrates improvement of cystic swelling (without recurrence) as well as other presenting complaints of the patient with individualised homoeopathic treatment.