Ganglioneuroblastoma in a newborn with multiple metastases: a case report

Gauchan, Eva; Sharma, Prakash; Ghartimagar, Dilasma; Ghosh, Arnab

doi:10.1186/s13256-017-1397-x

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…Disease recurrence occurs mostly in the first 2 years following. About 1% of tumors will metastasize to bone, liver, lung, brain, skin, or bone marrow, [ 17 ] via the hematogenous or lymphatic system. [ 8 ] Therefore, the patients should be followed closely (i.e., every 3 months for the first and second years, then every 6 months thereafter).…”

Section: Discussionmentioning

confidence: 99%

Primary cervical ganglioneuroblastoma

et al. 2018

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Rationale:Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs in the parapharyngeal space.Patient concerns:A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome.Diagnose:Computed tomography (CT) scan revealed a giant mass with irregular low density in left oropharyngeal and posterior pharyngeal wall. The left carotid artery sheath was pushed to the right. After enhancement, the central part of the mass was strengthened, and the surrounding bones structures appeard normal. Magnetic resonance imaging (MRI) showed a solid mass in the left parapharyngeal space displacing the left carotid sheath posteriorly and laterally. A ganglioneuroblastoma was diagnosed.Intervations:The girl was treated by surgery.Outcomes:The postoperative course was uneventful. There was no recurrence was observed during the 1-year follow-up.Lessons:The primary cervical ganglioneuroblastoma is rare, we recommended the ganglioneuroblastoma should be considered in the differential diagnosis of a child presenting with a parapharyngeal space mass.

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Section: Discussionmentioning

confidence: 99%

Primary cervical ganglioneuroblastoma

et al. 2018

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“…Cranial nerve paralysis may occur. Particularly after the resectioning of neuroma or paraganglioma tumors of this region, the paresis of these cranial nerves has a poor prognosis (8). In our case, no cranial nerve paresis was observed after the ganglioneuroblastoma was excised.…”

Section: Discussionmentioning

confidence: 47%

“…Therefore, patients should be followed every three months in the first two years and every six months thereafter. It should be noted that high levels of catecholamines may also be associated with recurrence (8).…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroblastoma; A Rare Tumor in Parapharyngeal Space

Ulu¹,

Kınar²,

Bucak³

2020

Erciyes Med J

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Background: Ganglioneuroblastoma is a malignant tumor, usually found in the adrenal glands, retroperitoneal ganglions or posterior mediastinum. In the head and neck region, Ganglioneuroblastoma is presented as a sub-type of neuroblastoma that originated from the sympathetic chain. It is often found in the retropharyngeal area, and if it involves the neck region, it is often found in the carotid space posterior to vascular sheat. Case Report: A 5-year-old girl was admitted to the pediatrics clinic with the complaint of a mass on the right side of her neck for about six months. Ultrasonography was carried out as an initial diagnostic tool, and it revealed a solid homogeneous mass. As a second-line diagnostic imaging method, Magnetic Resonance Imaging (MRI) was performed. The T2 weighted MRI sections showed a hyperintense mass was observed with an axial diameter of 37×40 mm and a craniocaudal diameter of 6 cm in the right parapharyngeal and prevertebral space. Although fine-needle aspiration biopsy (FNAB) was the first preferred biopsy method for neck masses, the FNAB report was inadequate. An incisional biopsy was carried out, and the pathology report described the tumor as ganglioneuroma. There were no immature/neuroblastic components in the serial sections. The patient was operated on transcervically. In the final pathology report, the tumor was described as ganglioneuroblastoma, intermixed type. After multidisciplinary consultations, the patient is still being followed with no further additional chemotherapy or radiotherapy. Conclusion: Ganglioneuroblastoma is a rare tumor in the parapharyngeal region. A multidisciplinary approach is especially important in such kind of rare tumors.

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“…In between lie GNBs, which are characterized by a mixture of cells ranging from primitive neuroblasts to well-differentiated ganglion cells within neurofibromatous tissues. [ 3 ] GNBs can be further sub-classified into 2 types: nodular and intermixed. [ 3 ] It is a transitional tumor of sympathetic origin, which has not yet been described as primarily involving the orbit.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3 ] GNBs can be further sub-classified into 2 types: nodular and intermixed. [ 3 ] It is a transitional tumor of sympathetic origin, which has not yet been described as primarily involving the orbit. The most common sites of GNB origin are the adrenal medulla, extra-adrenal retroperitoneum, and posterior mediastinum.…”

Section: Introductionmentioning

confidence: 99%

Primary orbital ganglioneuroblastoma in a child

Zhang

He²

2020

Medicine

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Rationale: Ganglioneuroblastoma (GNB) is a transitional tumor of sympathetic origin that has never been described as primarily involving the orbit. Herein we report an extremely rare case of GNB with primary orbital involvement and its treatment strategies. Patient concerns: A 9-year-old girl presented with progressive and recurring right orbital mass for 2 years. Diagnosis: Computed tomography (CT) showed a well-defined, well-circumscribed, and homogeneous extraconal soft tissue mass occupying most of the right superior orbital area. Magnetic resonance imaging (MRI) revealed that there was a neoplasm of the right superior orbit molding around the globe with long T1 and T2 signals, and contrast-enhanced MR image showed a heterogeneous enhancement of the mass. Histopathologic examinations were performed after surgery and the characteristics were consistent with a diagnosis of GNB. Interventions: Surgery was performed and the mass was completely resected. Outcomes: Postoperatively, the patient was on a regular follow-up for 19 months and so far, has had no orbital mass recurrence. Lessons: Herein we present a rare case of GNB primarily involving the orbit, and the findings showed that GNB could originate from the orbit. The patient underwent surgical tumor resection. The histopathological and immunohistochemical features were consistent with the diagnosis of GNB. For this case, there was no recurrence for 19 months after complete surgical excision of the tumor; however, a regular long-term follow-up is required.

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Ganglioneuroblastoma in a newborn with multiple metastases: a case report

Cited by 11 publications

References 8 publications

Primary cervical ganglioneuroblastoma

Primary cervical ganglioneuroblastoma

Ganglioneuroblastoma; A Rare Tumor in Parapharyngeal Space

Primary orbital ganglioneuroblastoma in a child

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