Ganglioneuroma, Base of Tongue: A Rare Entity

Mahajan, Nidhi; Bharti, Jyotsna Naresh; Singh, Meeta; Agarwal, Swapnil; Khurana, Nita

doi:10.7860/jcdr/2013/6042.3387

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Peripheral neuroblastic tumors are considered to originate from the progenitor cells of the neural crest [ 17 ]. A case of human ganglioneuroma on the base of the tongue similar to the present case has been previously reported [ 9 ]. In the human tongue, ganglia exist in the lateral margin or just below the taste buds, in the subepithelial nerve plexus [ 11 ], although, this area is an unusual site of ganglioneuromas [ 9 ].…”

supporting

confidence: 67%

“…A case of human ganglioneuroma on the base of the tongue similar to the present case has been previously reported [ 9 ]. In the human tongue, ganglia exist in the lateral margin or just below the taste buds, in the subepithelial nerve plexus [ 11 ], although, this area is an unusual site of ganglioneuromas [ 9 ]. In contrast, dogs have hemiganglia in the base of the vallate papillae and foliate papillae, which are located in the base of the dorsal tongue [ 2 , 7 ].…”

supporting

confidence: 67%

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Lingual ganglioneuroma in a dog

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Yonemaru

Hirata

et al. 2018

The Journal of Veterinary Medical Science

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A mass was found at the base of the dorsum linguae of a male 11-year-old Labrador retriever. The tumor comprised of ganglion cells and Schwannian cells with Verocay bodies. The ganglion cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and beta III tubulin. The Schwannian cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and glial fibrillary acidic protein. The lingual mass was diagnosed as a ganglioneuroma. To our knowledge, there has been no previous report of a lingual ganglioneuroma in a dog.

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supporting

confidence: 67%

supporting

confidence: 67%

Lingual ganglioneuroma in a dog

Goto

Yonemaru

Hirata

et al. 2018

The Journal of Veterinary Medical Science

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“…Ganglioneuromas have been rarely reported in the tongue. 14,15 Clinically, cervical ganglioneuromas usually cause sign and symptoms related to compression of nerves or vessels of the neck. 13 Histologically, they are well-defined and encapsulated masses, characterized by clusters of mature ganglion cells surrounded by fascicles of Schwann-like cells with decreased number of axons.…”

Section: Discussionmentioning

confidence: 99%

Subgemmal Neurogenous Plaque: A Clinical and Pathologic Review With Comparison to Common Head and Neck Neural Tumors

Alnajar

O’Toole

Lin

et al. 2019

Clin Med�Insights�Pathol

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Objective: In humans, subgemmal neurogenous plaques (SNPs) are normally found associated with taste buds. On histology, SNP may be mistaken for a neural neoplasm. The objective of this study was to correctly differentiate SNP among head and neck neural lesions and provide clinical and pathologic information that may assist in avoiding misdiagnosis. To our knowledge, this is the first study to provide an estimate of the degree of overdiagnoses of mucosal lesions in the head and neck mucosal area. Study design: Retrospective pathology and chart review. Methods: All cases of head and neck mucosal neural lesions only in the mucosa of the oral cavity, oropharynx, or larynx from the pathology archives of a single urban tertiary care center between 3/2000 and 6/2017 were obtained. The pathologic and clinical data were reviewed. Results: Twenty-six cases were identified: 9 neuromas, 9 neurofibromas, 2 ganglioneuromas and 6 cases of hyperplastic subepithelial nerve bundles. The mean greatest dimension of SNPs was 2.0 mm (range 1-3 mm) and most were subjacent to taste buds (13 cases). The 20 cases of SNP involved 15 women and 5 men. Their median age was 60 years (range 30-85 years). Clinical data were available in 19 cases. The most common presenting complaint was of a painless lesion (8 patients). Conclusions: This review confirmed the rarity of true neural neoplasms in the head and neck mucosa and estimates the risk of their over diagnosis given the possible diagnostic confusion with SNP.

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