Ganglioneuroma Originating From the Trigeminal Nerve in the Middle Cranial Fossa

Nakaguchi, Hiroshi; Murakami, Mineko; Matsuno, Akira; Yamazaki, Kazuto; Ishida, Yasuo

doi:10.2176/nmc.52.95

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…Ganglioneuromas (GN) are benign tumors of neural crest origin, which arise from the peripheral nervous system or adrenal glands. Intracranial involvement of GN is extremely rare and there have been only six cases reported of GN arising from the trigeminal nerve until 2017 [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Trigeminal Ganglioneuroma: A rare case of trigeminal neuralgia caused by Meckel’s cavum tumor: a case report and review of the literature

Mostarchid¹,

Mostarchid²,

Allaoui³

et al. 2022

World J. Adv. Res. Rev.

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Background: Ganglioneuroma (GN) is a rare benign tumor originating from the sympathetic nerves, and its origination from the trigeminal nerves is even rarer. Only six cases of GN originating from the trigeminal nerve have previously been reported. Aim: To report a very rare case of GN arising in Mikel's cave revealed by atypical trigeminal neuralgia. Case report: A 24-Year-old Moroccan man presented left trigeminal neuralgia. Intracranial MRI showed a 4.4 x 2.5 x 3 cm well-circumscribed multilobular mass in the posterior middle fossa and the petroclival area with compression to the medial temporal lobe. The tumor appeared homogeneously hypointense on T1WI, and hyperintense on T2WI and T2WI-Flair, and showed heterogeneous moderate enhancement. Bone window petrous CT scan showed thinning and remodeling bone on the left petrous apex. The preoperative diagnosis was cystic schwannoma. The patient underwent a subtemporal extradural approach with total removal of the lesion. The histological and immunohistochemically study confirmed the diagnosis of GN. Postoperative was marked by left keratitis for two months. No recurrence was documented on 3 years follow-up. Conclusion: we described a benign and extremely rare trigeminal ganglioneuroma. This case is the seven-reported case in the literature. The subtemporal interdural approach must be considered in the surgical approach of trigeminal Meckel's GN. Trigeminal GN should be considered in the differential diagnosis of the tumor found in Mickel's cavum.

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Section: Introductionmentioning

confidence: 99%

Trigeminal Ganglioneuroma: A rare case of trigeminal neuralgia caused by Meckel’s cavum tumor: a case report and review of the literature

Mostarchid¹,

Mostarchid²,

Allaoui³

et al. 2022

World J. Adv. Res. Rev.

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“…However, GPNs can also be caused by compression of a nerve by a mass lesion. There is several reports where tumors are associated GPN 1 , 2 , 3 , 6) where ix nerve is compressed by extrinsic large size tumor in cerebello-pontine angle (CPA) but till today, there is no report of glossopharyngeal nerve ganglioneuroma or ganglioneuroma of ix nerve with pre-existing GPN. Here, we report a case of very small glossopharyngeal nerve ganglioneuroma near jugular foramen (JF) and the patient also had longstanding GPN.…”

Section: Introductionmentioning

confidence: 99%

“…Ganglioneuroma is a neural crest origin tumor commonly occurs in mediastinum, adrenal glands, and peripheral nervous system but very rarely it occur in cranial cavity. [1][2][3] Very few cases of intracranial ganglioneuroma arising from the trigeminal nerve have been reported in the literature. 2,3) Glossopharyngeal neuralgia (GPN) is a rare clinical condition characterized by intense lancinating pain in throat commonly triggered by swallowing 4) but also by talking, chewing, yawning, and laughing.…”

Section: Introductionmentioning

confidence: 99%

Ganglioneuroma of Glossopharyngeal Nerve in a Patient with Glossopharyngeal Neuralgia: A Case Report

Chowdhury

Rumi

Zainab

et al. 2020

NMC Case Report Journal

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Ganglioneuroma is a rare tumor. Such tumor arising from cranial nerve is further rare. So far our knowledge, in the literature there is no report of ganglioneuroma involving glossopharyngeal nerve. Here, we report a case of very small glossopharyngeal nerve ganglioneuroma and the patient also had longstanding glossopharyngeal neuralgia (GPN). Case Report: A 40-year-old male diagnosed case of left GPN for last 7 years presented with gradual unresponsiveness of drug for last 5 years. Due to severity of pain sometime, he wished to do suicide. Magnetic resonance imaging (MRI) of head revealed only suspected loop of vessel in root entry zones of 9th and 10 cranial nerves on left side. The patient underwent explorative posterior fossa craniotomy. Careful dissection of arachnoid over 9th cranial nerve near jugular foramen (JF) revealed thick and red color nerve with nodularity (tumor like). Dissection of arachnoid at nerve root entry zones of 9th and 10th nerves also revealed an aberrant loop of posterior inferior cerebellar artery (PICA). The 9th nerve was transected and suspected “tumorous portion” of nerve was sent for histopathological examination. The PICA loop was dissected away from root entry zones by placing muscle and surgical between 10th nerve roots and PICA loop. He made an uneventful recovery. Histopathological examination revealed ganglioneuroma. Immunohistochemistry confirmed ganglioneuroma. Six months after the operation, he was free of symptoms. In this case, probably previously existing GPN was worsen by the growth of ganglioneuroma and surgical treatment brought gratifying result.

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“…gion, [2][3][4][5][6][7][8] with only three cases has been reported arising from trigeminal nerve. [2][3][4] The current paper presents a 49-year-old male patient with a ganglioneuroma arising from right trigeminal ganglion and extending to the middle-posterior cranial fossa.…”

mentioning

confidence: 99%

“…[2][3][4] The current paper presents a 49-year-old male patient with a ganglioneuroma arising from right trigeminal ganglion and extending to the middle-posterior cranial fossa. We summarized the clinical and diagnostic characteristics of this extremely rare tumor, in comparison with the three reported cases in literatures.…”

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confidence: 99%

Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report△

Wang

Lou

et al. 2017

Chinese Medical Sciences Journal

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CASE DESCRIPTIONA 49-year-old male patient with no previous comorbidities presented to our hospital with a main complaint of discontinuous dizziness for one month. The dizziness was paroxysmal onset without obvious cause. General physical examination demonstrated right facial muscle atrophic, with no other abnormality. All the neurologic examination was negative.Computed tomography (CT) scan of the brain discovered a slight hypodensity mass (4.2cm×5.2cm) in the right middle-posterior cranial fossa with internal high-density dots in the tumor (Fig. 1A). The tumor deformed the ethmoid bone, destroyed the greater wing of the sphenoid bone and the petrous apex area, and extended to the carvernous sinus and posterior cranial fossa. The pons was compressed. CT value of the spotty high-density was about 350HU, consistent with localized intratumoral calcification and hemorrhage. CT images in bone window demonstrated absorption and thinning of the sphenoid and ethmoid bone without destruction (Fig. 1B). The brain magnetic resonance imaging (MRI) showed a 4.1cm×5.4cm×4cmwell-circumscribed extra-axial mass in the parasellar and cerebellopontine angle region of right middle-posterior cranial fossa (Fig. 2). The right fifth-sixth cranial nerve was displaced by the mass. The lesion demonstrated heterogeneous isointensity or slight hypointensity on T1-weighted image (T1WI), heterogeneous hyper-to slight hypointensity on T2-weighted image (T2WI) (Fig. 2A). It compressed G

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Ganglioneuroma Originating From the Trigeminal Nerve in the Middle Cranial Fossa

Cited by 7 publications

References 15 publications

Trigeminal Ganglioneuroma: A rare case of trigeminal neuralgia caused by Meckel’s cavum tumor: a case report and review of the literature

Trigeminal Ganglioneuroma: A rare case of trigeminal neuralgia caused by Meckel’s cavum tumor: a case report and review of the literature

Ganglioneuroma of Glossopharyngeal Nerve in a Patient with Glossopharyngeal Neuralgia: A Case Report

Trigeminal Ganglioneuroma in the Middle-posterior Cranial Fossa: a Case Report△

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