Ganglioneuroma with leiomyomatosis of the urinary bladder: A rare tumor causing frequent micturition and dysuria

Wang, Qi; Min, Jie; Zhang, Tao; Xie, Dong; Wang, Yi; Ding, Demao; Chen, Lei; Zou, Ci; Ma, Jiaxing; Zhang, Zhiqiang; Wang, Da-Ming; Yu, Dexin

doi:10.5489/cuaj.1491

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Bladder ganglioneuroma is extremely rare in adults, and only three such cases were reported in children so far [ 1 , 5 , 6 ]. Ganglioneuromas account for less than 0.5% of all primary bladder tumors in adults and may cause urinary tract obstruction, lower urinary tract symptoms (gross hematuria, urinary tract infection, dysuria), and pelvic pain, as well as hypertension [ 7 ]. Sometimes dysfunctional voiding and urinary retention related to mass localization can occur; aggressive surgery and adequate antibiotic therapy is needed [ 2 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroma of the Bladder in Association with Neurofibromatosis Type 1

et al. 2022

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Neurofibromatosis type 1 (NF1) is a genetic disease, with autosomal dominant transmission, related to pathogenic variant of the tumor suppressor gene NF1 (17q11.2), predisposing affected subjects to a variety of benign (neurofibromas and plexiform neurofibromas) and malignant tumors. The lack of the NF1-neurofibromin gene product can cause uncontrolled cell proliferation in the central or peripheral nervous system and multisystemic involvement, and so the disease includes a heterogeneous group of clinical manifestations. Ganglioneuromas are benign tumors developing from the neural crest cells of the autonomic nervous system, considered to be part of neuroblastic tumors. Bladder localization is extremely rare in adults, and only three such cases were reported in children so far. The aim of our study, in addition to a brief review of the literature of these pathologies, is to bring to your attention the case of a sixteen year old patient with a very rare association of NF1 and bladder ganglioneuroma, who presented at the hospital with gross hematuria. Since bladder ganglioneuroma is a rare pathological condition, the differential diagnosis is difficult and imaging investigations and pathological investigations are the ones that elucidate this disease. The clinical approach of the medical multidisciplinary team involved should help the patient in managing her medical and surgical situation.

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Section: Discussionmentioning

confidence: 99%

Ganglioneuroma of the Bladder in Association with Neurofibromatosis Type 1

et al. 2022

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“…In addition, enhanced scans can also provide insights into the lesion's blood supply, the surrounding vessels and their relationship to the mass, tumor metastasis, and the extent of invasion, which can make a diagnosis of a typical ganglioneuroma and thus provide an accurate basis for surgical treatment. 15 Because ganglioneuromas are usually considered to be benign tumors, surgical resection is the main treatment and chemotherapy is generally not recommended. Depending on the location of the tumor and the quality of life requirements, some patients only underwent subtotal tumor resection, with no signs of tumor enlargement and no distant metastases after 7 months of postoperative follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, enhanced scans can also provide insights into the lesion’s blood supply, the surrounding vessels and their relationship to the mass, tumor metastasis, and the extent of invasion, which can make a diagnosis of a typical ganglioneuroma and thus provide an accurate basis for surgical treatment. 15 …”

Section: Discussionmentioning

confidence: 99%

A case of ganglioneuroma of the ureter and review of the literature

Ling¹,

Chen²,

Yuan³

2022

J Int Med Res

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Ganglioneuroma is a rare tumor originating from neural crest tissue of the sympathetic nervous system. We report on an approximately 55-year-old woman who was admitted to hospital with abdominal pain. Surgery revealed a tumor in her right ureter, which was pathologically confirmed as a ganglioneuroma. The patient underwent transabdominal total hysterectomy, bilateral adnexal resection, release of pelvic and intestinal adhesions, right ureteroscopy, right ureter retrograde intubation, right ureteral lesion excision, and ureteral anastomosis. A literature review indicated that most ganglioneuromas are benign tumors. Clinicians may consider total or subtotal tumor resection, depending on the tumor location and patient's condition. The patient’s clinical condition may improve after surgery combined with periodic long-term follow-up.

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“…Symptomatic progression is possible, however, as increased urinary frequency, hematuria, and dysuria have been reported in the adult literature. 14,15 This is because of tumor bleeding and local mass effect causing urinary symptoms. In addition, distinguishing benign tumors from malignant entities is often not possible until a sample is retrieved for pathologic analysis at the time of surgical resection.…”

Section: Commentmentioning

confidence: 99%