Gangliosides and Antigangliosides in Malignant Melanoma

Ene, Corina-Daniela; Nicolae, Ilinca

doi:10.5772/59176

Cited by 6 publications

(4 citation statements)

References 106 publications

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“…The present study showed no significant increase in quantitative determination of TuM2-PK in patients with T1N0Mo ccRCC compared with healthy subjects. The plasmatic level of TuM2-PK in patients with ccRCC was correlated with IL-8 levels, data that suggest a possible interaction between these markers and tumoral neoangiogensis [101][102][103][104][105][106]. A recent report showed that the extracellular level of TuM2-PK in patients with localized renal cell carcinoma was 3.2-fold lower compared with patients with disseminated disease [107].…”

Section: Discussionmentioning

confidence: 95%

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

et al. 2020

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Posttranslational modifications are dynamic enzymatic-mediated processes, regulated in time and space, associated with cancer development. We aimed to evaluate the significance of posttranslational modifications in the pathogenesis of clear cell renal cell carcinoma. The authors developed a prospective, observational study during a period of three years and included 55 patients with localized renal cell carcinoma and 30 heathy subjects. Glycosylation, nitration and carbonylation, thiol-disulfide homeostasis, methylation, phosphorylation and proteolytic cleavage were evaluated in the serum of the evaluated subjects in the present study. Our results showed some characteristics for early ccRCC: high production of cytokines, substrate hypersialylation, induced nitrosative and carbonylic stress, arginine hypermethylation, thiol/disulfide homeostasis (TDH) alteration, the regulatory role of soluble receptors (sRAGE—soluble receptor for advanced glycation end products, sIL-6R—soluble receptor for Interleukin 6) in RAGE and IL-6 signaling, the modulatory effect of TK1—thymidine kinase 1 and TuM2-PK—tumoral pyruvate-kinase 2 in controlling the level of phosphometabolites in neoplastic cells. These data could be the initial point for development of a panel of biomarkers such as total sialic acid, orosomucoids, nitrotyrosine, carbonylic metabolites, Asymmetric Dimethylarginines (ADMA), Symmetric Dimethylarginines (SDMA), and thiol-disulfide equilibrium for early diagnosis of ccRCC. Moreover, they could be considered a specific disease posttranslational modification signature which underlines the transition from early to advanced stages in this neoplasia, and of a therapeutic target in kidney oncogenesis.

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Section: Discussionmentioning

confidence: 95%

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

et al. 2020

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“…The hypoxic microenvironment constitutes a developing area of investigation in solid tumours. Several studies have identified various soluble factors (such as different interleukins) in the neoplastic microenvironment involved in cancer development and progression (4)(5)(6)13,16,17,(26)(27)(28)(29). The current study explored the contribution of the angiogenic response to hypoxia and inflammation in PCa and BPH biology.…”

Section: Discussionmentioning

confidence: 99%

Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study

Cosmin,

Ilinca,

Daniela

2023

Exp Ther Med

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The present paper aimed to investigate the altered angiogenetic mechanisms in hypoxic conditions in patients with prostate tumours, in correlation with common clinicopathologic variables. A case-control study was developed and included 87 patients with prostate tumours [40 diagnosed with benign prostatic hyperplasia (BPH) and 47 diagnosed with prostate cancer (PCa), using prostate transrectal biopsy] and 40 healthy subjects. The following parameters were evaluated in the serum of volunteers: Hypoxia-inducible factor (HIF)-1α, fibroblast growth factor (FGF)-2, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and -9, thrombospondin (TSP)-1 and soluble VEGF-1 receptor. Experimental data analysis demonstrated increasing amounts of inflammation in patients with PCa (IL-6, 18.1±4.7 ng/ml) and BPH (IL-6, 16.3±5.1 ng/ml) vs. control (IL-6, 4.1±1.2 ng/ml); overregulation of HIF1α in patients with PCa (129.3±21.8 ng/ml) compared with patients with BPH (65.6±18.2 ng/ml) and control (61.3±12.7 ng/ml); angiogenesis abnormalities in patients with PCa (upregulation of FGF-2, VEGF, MMP-2 and -9, suppression of TSP-1 and soluble VEGR-1) and BPH (upregulation FGF-2 and VEGF) compared with the control group. In conclusion, a greater understanding of the biological mechanism, the pathological roles and the clinical significance of various proangiogenic parameters and angiogenic-suppressor proteins seem useful in clinical practice for establishing an early diagnosis of prostate pathology and finding an individualized therapeutic approach.

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“…They can act as receptors and various biological substances, contributing to the expression of immune cell functions. Accordingly, the possibility of their application for treating prostate cancer, 23 melanoma, 24 and diabetic nephropathy 25 has been suggested, and related research is being actively conducted. According to Nicolae et al., titers of anti-GDA1a and antiGQ1b (ganglioside antibodies) were higher in patients with BPH than in controls.…”

Section: Discussionmentioning

confidence: 99%

Cervi Parvum Cornu complex for men with lower urinary tract symptoms: a multicenter, randomized, double-blind, placebo-controlled trial

Shin,

Yoon,

Kim

et al. 2023

Prostate International

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Gangliosides and Antigangliosides in Malignant Melanoma

Cited by 6 publications

References 106 publications

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study

Cervi Parvum Cornu complex for men with lower urinary tract symptoms: a multicenter, randomized, double-blind, placebo-controlled trial

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